Evidence map›Paper›PMID 39912660›Full record

ArticleAntimicrobial agents and chemotherapy2025

Prediction of higher ceftazidime-avibactam concentrations in the human renal interstitium compared with unbound plasma using a minimal physiologically based pharmacokinetic model developed in rats and pigs through microdialysis.

Maxime Vallée, Vincent Aranzana-Climent, Jérémy Moreau, Isabelle Lamarche, Théo Fontanier, Céline Barc, Nathalie Kasal-Hoc, Céline Debiais-Delpech, Hélène Mirfendereski, Jérémy Pezant and 5 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maxime Vallée *Université de Poitiers, INSERM U1070, PHAR2, Poitiers, France.ORCID 0000-0001-9532-3723
Vincent Aranzana-Climent *Université de Poitiers, INSERM U1070, PHAR2, Poitiers, France.ORCID 0000-0002-1258-8054
Jérémy MoreauUniversité de Poitiers, INSERM U1070, PHAR2, Poitiers, France.
Isabelle LamarcheUniversité de Poitiers, INSERM U1070, PHAR2, Poitiers, France.
Théo FontanierUniversité de Poitiers, INSERM U1070, PHAR2, Poitiers, France.
Céline BarcPlateforme d'Infectiologie Expérimentale (PFIE), UE1277, INRAE Centre Val de Loire, Nouzilly, France.
Nathalie Kasal-HocPlateforme d'Infectiologie Expérimentale (PFIE), UE1277, INRAE Centre Val de Loire, Nouzilly, France.
Céline Debiais-DelpechService d'anatomopathologie, CHU de Poitiers, Poitiers, France.
Hélène MirfendereskiUniversité de Poitiers, INSERM U1070, PHAR2, Poitiers, France.
Jérémy PezantPlateforme d'Infectiologie Expérimentale (PFIE), UE1277, INRAE Centre Val de Loire, Nouzilly, France.
Anne PinardPlateforme d'Infectiologie Expérimentale (PFIE), UE1277, INRAE Centre Val de Loire, Nouzilly, France.
Jonathan ClarhautUniversité de Poitiers, INSERM U1070, PHAR2, Poitiers, France.
William CouetUniversité de Poitiers, INSERM U1070, PHAR2, Poitiers, France.ORCID 0000-0002-7116-8965
France Cazenave-RoblotUniversité de Poitiers, INSERM U1070, PHAR2, Poitiers, France.
Sandrine MarchandUniversité de Poitiers, INSERM U1070, PHAR2, Poitiers, France.ORCID 0000-0001-5279-6678

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Last resort antibiotics, like ceftazidime-avibactam (CZA), were used to treat urinary tract infections caused by multidrug-resistant bacteria. However, no data on tissue distribution were available. Our aim was to describe the

Indexed as

Anti-Bacterial AgentsAzabicyclo CompoundsCeftazidimeKidneyAnimalsDrug CombinationsHumansMaleMicrodialysisRatsSwineTissue DistributionAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsCeftazidimeDrug Combinationsceftazidime–avibactammicrodialysispharmacokineticsphysiologically based pharmacokinetic modelurinary tract infection

Identifiers

PMID39912660
PMCPMC11881572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.