Evidence map›Paper›PMID 39912506›Full record

ArticleACS biomaterials science & engineering2025

Spiked Systems for Colonic Drug Delivery: Architectural Opportunities and Quality Assurance of Selective Laser Sintering.

Angelos Gkaragkounis, Konstantina Chachlioutaki, Orestis L Katsamenis, Fernando Alvarez-Borges, Savvas Koltsakidis, Ioannis Partheniadis, Nikolaos Bouropoulos, Ioannis S Vizirianakis, Dimitrios Tzetzis, Ioannis Nikolakakis and 3 more

Abstract read
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In one paragraph

Article in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Angelos GkaragkounisLaboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki GR 54124, Greece.ORCID 0000-0001-5730-6818
Konstantina ChachlioutakiLaboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki GR 54124, Greece.
Orestis L Katsamenisμ-VIS X-Ray Imaging Centre, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton SO17 1BJ, U.K.ORCID 0000-0003-4367-4147
Fernando Alvarez-Borgesμ-VIS X-Ray Imaging Centre, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton SO17 1BJ, U.K.
Savvas KoltsakidisDigital Manufacturing and Materials Characterization Laboratory, School of Science and Technology, International Hellenic University, Thessaloniki 57001, Greece.
Ioannis PartheniadisLaboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki GR 54124, Greece.
Nikolaos BouropoulosDepartment of Materials Science, University of Patras, Patras 26504, Rio, Greece.
Ioannis S VizirianakisLaboratory of Pharmacology, Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki GR 54124, Greece.ORCID 0000-0003-1459-9774
Dimitrios TzetzisDigital Manufacturing and Materials Characterization Laboratory, School of Science and Technology, International Hellenic University, Thessaloniki 57001, Greece.
Ioannis NikolakakisLaboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki GR 54124, Greece.ORCID 0000-0003-1690-1885
Chris H J VerhoevenThe Netherlands Organization for Applied Scientific Research (TNO), Eindhoven 5656 AE, The Netherlands.ORCID 0009-0000-1526-8948
Dimitrios G FatourosLaboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki GR 54124, Greece.ORCID 0000-0003-2361-4198
Kjeld J C van BommelThe Netherlands Organization for Applied Scientific Research (TNO), Eindhoven 5656 AE, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Additive manufacturing has been a breakthrough therapy for the pharmaceutical industry raising opportunities for long-quested properties, such as controlled drug-delivery. The aim of this study was to explore the geometrical capabilities of selective laser sintering (SLS) by creating spiked (tapered-edged) drug-loaded specimens for administration in colon. Poly(vinyl alcohol) (PVA) was used as the binding material and loperamide hydrochloride was incorporated as the active ingredient. Printing was feasible without the addition of a sintering agent or other additives. Innovative printing protocols were developed to help improve the quality of the obtained products. Intentional vibrations were applied on the powder bed through rapid movements of the printing platform in order to facilitate rigidity and consistency of the printed objects. The drug-loaded products had physicochemical properties that met the pharmacopoeia standards and exhibited good biocompatibility. The behavior of spiked balls (spherical objects with prominent spikes) and their retention time in the colon was assessed using a custom

Indexed as

ColonDrug Delivery SystemsLasersLoperamideAnimalsHumansPolyvinyl AlcoholPrinting, Three-DimensionalLoperamidePolyvinyl Alcohol3D printingcolonic drug deliveryextended retention timeloperamidemucoadhesionselective laser sinteringspiked drug delivery systems

Identifiers

PMID39912506
PMCPMC11897947

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.