Evidence map›Paper›PMID 39912405›Full record

ReviewJournal of enzyme inhibition and medicinal chemistry2025

Exploring covalent inhibitors of SARS-CoV-2 main protease: from peptidomimetics to novel scaffolds.

Noor Atatreh, Radwa E Mahgoub, Mohammad A Ghattas

Abstract readReview
In one paragraph

Review in Journal of enzyme inhibition and medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Access toACS organic & inorganic Au · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Noor AtatrehCollege of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates.
Radwa E MahgoubCollege of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates.
Mohammad A GhattasCollege of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates.ORCID 0000-0002-2240-8037

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptidomimetic inhibitors mimic natural peptide substrates, employing electrophilic warheads to covalently interact with the catalytic Cys145 of M

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesCOVID-19 Drug TreatmentPeptidomimeticsProtease InhibitorsSARS-CoV-2HumansStructure-Activity Relationship3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesPeptidomimeticsProtease InhibitorsAnti-viralcovalent inhibitorCovid-19irreversible inhibitionwarheads reactivity

Identifiers

PMID39912405
PMCPMC11803818

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.