ArticleJournal of medical virology2025
Viral Load of Human Papillomavirus (HPV) During Pregnancy and Its Association With HPV Vertical Transmission.
Article in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human Papillomavirus Across the Reproductive Lifespan: An Integrative Review of Fertility, Pregnancy Outcomes, and Fertility-Sparing Management.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Relative HPV Viral Load Measured by ΔCt for Risk Stratification in Cervical Cancer Screening.Cancers · 2026Article
- Review
- Article
- Optimizing Pregnancy Outcomes: The Role of Gynecologists in Preconceptional Care in Italy.International journal of women's health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Little is known on the dynamics of human papillomavirus (HPV) viral load during pregnancy and on the impact of viral load on HPV vertical transmission. We described viral loads for several genotypes during pregnancy and analyse its association with vertical transmission. Data were analysed from the HERITAGE study, a cohort of pregnant women recruited between 2010 and 2016 in three centres in Canada. Vaginal samples were collected at the first and third trimesters of pregnancy, placental samples were collected at birth, and conjunctival, oral, pharyngeal, and genital samples were collected in children at birth and 3 months were tested for HPV DNA and viral load by Linear Array essay. The association between viral load and vertical transmission was measured using logistic regression. Odd ratios (ORs) and their 95% Confidence intervals (CI) were adjusted for age of the mother. We included women in the cohort infected with the 13 most common genotypes during pregnancy (n = 287). A decrease in HPV viral load was observed during pregnancy (median difference between the third and first trimester of pregnancy = -0.005 copies/cell [p < 0.05]). Women with more than 2 HPV copies/cell (compared to those with ≤ 2 copies) at first trimester had a statistically significant higher risk of vertical transmission (adjusted OR = 6.41; 95% CI: 1.10-37.34 for any genotypes and OR = 17.17; 95% CI: 1.18-250.28 for HPV-16). Viral load values analysed continuously or categorized with different cut-offs showed comparable results. HPV viral load varied during pregnancy and was strongly associated with HPV vertical transmission. The results provide a better understanding of risk factors associated with vertical transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.