Evidence map›Paper›PMID 39912392›Full record

ReviewCurrent opinion in clinical nutrition and metabolic care2025

Concurrent nutrition and physical rehabilitation interventions for patients with critical illness.

Felipe González-Seguel, Kirby P Mayer, Renee D Stapleton

Abstract readReview
In one paragraph

Review in Current opinion in clinical nutrition and metabolic care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Interruption of enteral tube feeding during chest physiotherapy in critically ill adults: A scoping review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Felipe González-SeguelDepartment of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, USA.
Kirby P MayerDepartment of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, USA.
Renee D StapletonPulmonary and Critical Care Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont, USA.

Funding

Nutrition and Exercise in Critical Illness (The NEXIS Trial): A Randomized Trial of Combined Cycle Ergometry and Amino Acids in the ICUR01HL132887 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HEYLAND, DAREN KEITH, NEEDHAM, DALE MURRAY · 2017 to 2021
$3.5M
Effects of Exercise on Inflammation-Induced Lung and Muscle Injury in Critical Illness (NEXIS-FLAME)R01HL143452 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI FILES, DANIEL CLARK, POYNTER, MATTHEW E · 2018 to 2021
$3.2M
NHLBI NIH HHS R01 HL132887NHLBI NIH HHS R01 HL143452
6 · The paper itself

Abstract

purpose of reviewThe effects of either physical rehabilitation or nutrition on outcomes in patients with critical illness are variable and remain unclear. The potential for the combination of exercise and nutritional delivered concurrently to provide benefit is provocative, but data are only emerging. Herein, we provide a summary of evidence from 2023 and 2024 on combined physical rehabilitation and nutrition during and following critical illness. RECENT

findingsWhile latest trials on physical rehabilitation alone reported conflicting findings, recent nutrition trials found no difference between higher and lower protein delivery and even suggested harm in patients with acute kidney injury. In 2023 and 2024, we identified four studies (one randomized controlled trial) combining physical rehabilitation and nutrition (mainly protein supplementation) within the ICU setting. Overall, these suggested benefits, including reduction of muscle size loss, ICU acquired weakness, delirium, and improved mobility levels, although these benefits did not extend to mortality and hospital length of stay. No recent trials combining physical rehabilitation and nutrition for patients after ICU were identified. SUMMARY: Current insights on combined physical rehabilitation and nutrition suggest improved clinically relevant outcomes, but further investigations across the continuum of care of patients with critical illness are warranted.

Indexed as

Critical CareCritical IllnessExercise TherapyNutrition TherapyCombined Modality TherapyHumansIntensive Care UnitsNutritional StatusRandomized Controlled Trials as Topic

Identifiers

PMID39912392
PMCPMC11803140

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.