Evidence map›Paper›PMID 39912008›Full record

ArticleCureus2025

Cardiac Kaposi Sarcoma Complicated by Kaposi Sarcoma Inflammatory Cytokine Syndrome: A Case Report.

Anna-Maria B Dagher, Jeffrey Lee, Hayley E Cunningham, Julian J Weiss, Michael E Yarrington

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anna-Maria B DagherInternal Medicine, Duke University School of Medicine, Durham, USA.
Jeffrey LeeInternal Medicine, Duke University School of Medicine, Durham, USA.
Hayley E CunninghamInfectious Diseases, Duke University School of Medicine, Durham, USA.
Julian J WeissInternal Medicine, Duke University School of Medicine, Durham, USA.
Michael E YarringtonInfectious Diseases, Duke University School of Medicine, Durham, USA.

Funding

Ruth L. Kirschstein National Research Service Award (NRSA)- T32T32AI007392 · NIAID · DUKE UNIVERSITY · PI Amy Lynn Corneli, Guido Ferrari · 1990 to 2026
$9.8M
NIAID NIH HHS T32 AI007392
6 · The paper itself

Abstract

Kaposi sarcoma (KS), caused by human herpesvirus-8 (HHV-8), is among the most common malignancies in people living with HIV. Kaposi sarcoma is an angiogenic endothelial cell neoplasm and an acquired immunodeficiency syndrome (AIDS)-defining illness. Kaposi sarcoma is associated with high mortality when presenting as visceral or disseminated disease or when complicated by Kaposi sarcoma inflammatory cytokine syndrome (KICS), immune reconstitution inflammatory syndrome, or multicentric Castleman disease. We present the case of a 26-year-old male patient found to have AIDS-related KS complicated by cardiac, pulmonary, gastrointestinal, and skin involvement as well as KICS. Notably, the patient's skin lesions were not identified at the initial hospital presentation. He was treated with doxorubicin for KS and rituximab for KICS but died shortly after KICS diagnosis. We highlight the importance of recognizing KS skin lesions to aid in early diagnosis and of recognizing signs and symptoms of KICS to expedite immunomodulatory therapy initiation.

Indexed as

cardiac kaposi sarcomacase reportdisseminated kaposi sarcomahiv aidsimmune reconstitution inflammatory syndromekshv inflammatory cytokine syndrome (kics)pulmonary kaposi sarcoma

Identifiers

PMID39912008
PMCPMC11794192

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.