A Pilot Study Characterization of the Scalp Microbiome in Central Centrifugal Cicatricial Alopecia Shows Shift in

Hunter J Pyle, Taylor Dyson, Aditi Gadre, Tamia A Harris-Tryon, Crystal Aguh

Abstract read

In one paragraph

Article in Skin appendage disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

The Scalp Microbiome-Hair Axis: Mechanisms and Therapeutic Translation.Research (Washington, D.C.) · 2026
Review

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hunter J PyleDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Taylor DysonDepartment of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Aditi GadreDepartment of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Tamia A Harris-TryonDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Crystal AguhDepartment of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Aberrant fibrosis in central centrifugal cicatricial alopecia (CCCA) is thought to be driven by persistent low-grade inflammation, but the source of inflammation is unclear. Alterations in the scalp microbiota may contribute to inflammation and thus provide a target for therapeutic intervention. We sought to compare the bacterial and fungal cutaneous scalp microbiota in patients with CCCA versus controls. Methods: Six patients with CCCA and seven controls were sampled at the vertex scalp. 16S rRNA sequencing of V3-V4 region and internal transcribed spacer amplicon sequencing was used to compare bacterial and fungal microbiomes. Results: A significantly higher relative abundance of Limitations: V3-V4 sequencing can be limited in detection of major skin bacterial species. Conclusion: CCCA is characterized by a distinct bacterial microbiome community and high relative abundances of

Indexed as

AlopeciaCentral centrifugal cicatricial alopeciaClinical researchCorynebacteriumMicrobiomeScarring alopeciaSkin microbiome

Identifiers

PMID39911984

DOI10.1159/000539763

PMCPMC11793899

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.