ArticleClinical and translational radiation oncology2025
Postoperative brachytherapy alone for 217 patients with early-stage oral cavity squamous cell carcinoma.
Article in Clinical and translational radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The Role of Brachytherapy in the Management of Oral Squamous Cell Carcinoma: A Systematic Review.Journal of clinical medicine · 2025Review
- Comparison of dose calculation approaches and clinical dose-response in image-guided head&neck brachytherapy of the oral cavity.Clinical and translational radiation oncology · 2025Article
- The doses to Organs at risk and their Proximity to target volumes are crucial Determinants of brachytherapy toxicity.Clinical and translational radiation oncology · 2025Article
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7 authors.
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Abstract
Introduction: Postoperative radiotherapy is generally recommended for pT1/2pN0 squamous cell carcinoma of the oral cavity (OSCC) if risk factors are present. Prospective studies are missing. Interventional radiotherapy offers a precise dose application. In this paper we analyze long-term efficacy and toxicity in a large single-center cohort of patients with early OSCC receiving sole postoperative brachytherapy (BT). Material and methods: From 1998 to 2023, 217 patients were postoperatively treated with sole BT in our institute. The median follow-up was 110 months (range: 2-316). The primary objective was local control. Secondary outcomes were overall survival, cancer specific survival, and toxicity. Results: The local recurrence rates for 12, 24, and 60 months were 7.1 %, 9.1 %, and 12.6 %. The disease-free survival was 89.7 %, 86.1 %, and 79.3 %. The overall survival rates at 12, 24, and 60 months were 94.4 %, 89.6 %, and 77.9 %. The cancer-specific survival was 97.1 %, 96.6 %, and 92.9 %, respectively. At two years, the rate of regional recurrence was 8.3 %. Patients without neck dissection had a significantly increased risk for lymph node recurrence (p = 0.025). Side effects ≥ grade 3 were seen in 14 % (30/217). 17 % (37/217) of patients developed a soft tissue necrosis (STN). Osteoradionecrosis (ORN) was seen in 7 % (15/217) of patients. A target volume > 15 cm Conclusions: Postoperative interventional radiotherapy for previously not irradiated patients with early-stage OSCC is a safe and efficient treatment. Randomized trials are needed to compare these results to omission of postoperative radiotherapy as well as external beam radiotherapy.
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