Structure-activity relationships in the development of single atom catalysts for sustainable organic transformations.

Single atom catalysts (SACs), which can provide the combined benefits of homogeneous and heterogeneous catalysts, are a revolutionary concept in the field of material research. The highly exposed catalytic surfaces, unsaturated sites, as well as unique structural and electronic properties of SACs have the potential to catalyze numerous reactions with unmatched efficiency and durability when stabilized on a suitable support. In this review, we have provided an intuitive insight into the strategies adopted in the last 5 years for morphology control of SACs to know about its impact on metal-support interaction and various organic transformations with special reference to metal oxides, alloys, metal-organic frameworks (MOFs) and carbon-based supports. This review also includes a brief description of unparalleled potentials of SACs and the recent advances in the catalysis of industrially important organic transformations, with special emphasis on the C-C cross-coupling reaction, biomass conversion, hydrogenation, oxidation and click chemistry. This unprecedented and unique perspective will highlight the interactions occurring within SACs that are responsible for their high catalytic efficiency, which will potentially benefit various organic transformations. We have also suggested plausible synergy of various other concepts such as defect engineering and piezocatalysis with SACs, which can provide a new direction to sustainable chemistry. A good understanding of the different types of metal-support interactions will help researchers develop morphology-controlled SACs with tunable properties and establish mechanisms for their exceptional catalytic behaviour in industrially important organic transformations.