ArticleNature. Mental health2024
A cognitive neural circuit biotype of depression showing functional and behavioral improvement after transcranial magnetic stimulation in the B-SMART-fMRI trial.
Article in Nature. Mental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Variation in the costs and ecological benefits of tropical natural forest regeneration.Nature ecology & evolution · 2026Article
- The mPFC-reuniens-hippocampus pathway links brain circuitry and neural plasticity in antidepressant response.Nature communications · 2026Article
- The Effect of Single Pulse TMS on Working Memory Performance: An Online TMS And fNIRS Study.medRxiv : the preprint server for health sciences · 2026Article
- Trials, trips, and tribulations: pathways for implementing psychedelic therapy in Ireland.The international journal of neuropsychopharmacology · 2026Review
- Distinct Biotypes of Visual Perception in Major Depressive Disorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Developing Clinically Interpretable Neuroimaging Biotypes in Psychiatry.Biological psychiatry · 2026Review
- Network-based analysis of differential white matter connectivity in major depressive disorder with and without comorbid anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Cognitive biotypes identified through ECG-derived workload and behavioral accuracy.Scientific reports · 2026Article
- Bridging the dimensional gap from planar spatial transcriptomics to 3D cell atlases.Nature methods · 2026Article
- Cognition in Treatment-Resistant Depression: Obstacles and Challenges?Advances in experimental medicine and biology · 2026Review
- Circuit-Based Approaches to Understanding the Anterior Cingulate Cortex (ACC).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Transdiagnostic connectome-based predictive modeling of many behavioral phenotypes reveals brain network mediators of clinical-cognitive relationships.bioRxiv : the preprint server for biology · 2025Article
- Neurostimulation to Improve Cognitive Flexibility.Current opinion in behavioral sciences · 2025Article
- Cognitive and motor disturbances in depression: insights from comprehensive behavioral assessments.Frontiers in psychiatry · 2025Article
- Towards closed-loop precision psychiatry: Integrating MRI biomarkers for individualized care of major depressive disorder.Psychoradiology · 2025Review
- Personalized models of Beam/F3 targeting in transcranial magnetic stimulation for depression: Implications for precision clinical translation.Brain stimulationArticle
- Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
We previously identified a cognitive biotype of depression characterized by treatment resistance, impaired cognitive control behavioral performance and dysfunction in the cognitive control circuit, comprising the dorsolateral prefrontal cortex (dLPFC) and dorsal anterior cingulate cortex (dACC). Therapeutic transcranial magnetic stimulation (TMS) to the left dLPFC is a promising option for individuals whose depression does not respond to pharmacotherapy. Here, 43 veterans with treatment-resistant depression were assessed before TMS, after early TMS and post-TMS using functional magnetic resonance imaging during a Go-NoGo paradigm, behavioral cognitive control tests and symptom questionnaires. Stratifying veterans at baseline based on task-evoked dLPFC-dACC connectivity, we demonstrate that TMS-related improvement in cognitive control circuit connectivity and behavioral performance is specific to individuals with reduced connectivity at baseline (cognitive biotype +), whereas individuals with intact connectivity at baseline (cognitive biotype -) did not demonstrate significant changes. Our findings show that dLPFC-dACC connectivity during cognitive control is both a promising diagnostic biomarker for a cognitive biotype of depression and a response biomarker for cognitive improvement after TMS applied to the dLPFC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.