Evidence map›Paper›PMID 39911676›Full record

ArticleFrontiers in medicine2024

The amplitude of low frequency fluctuation and spontaneous brain activity alterations in age-related macular degeneration.

Yan Yan Zhang, Jin Yu Hu, Qian Ling, San Hua Xu, Min Kang, Hong Wei, Jie Zou, Quanyong Yi, Gang Tan, Yi Shao

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Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yan Yan Zhang *Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, China.
Jin Yu Hu *Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of National Clinical Research Ophthalmology Center, Nanchang, China.
Qian Ling *Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of National Clinical Research Ophthalmology Center, Nanchang, China.
San Hua XuDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of National Clinical Research Ophthalmology Center, Nanchang, China.
Min KangDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of National Clinical Research Ophthalmology Center, Nanchang, China.
Hong WeiDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of National Clinical Research Ophthalmology Center, Nanchang, China.
Jie ZouDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Centre of National Clinical Research Ophthalmology Center, Nanchang, China.
Quanyong YiNingbo Eye Hospital, Wenzhou Medical University, Ningbo, China.
Gang TanDepartment of Ophthalmology, The First Affiliated Hospital of University of South China, Hunan Center of National Ocular Disease Clinical Research Center, Hengyan, China.
Yi ShaoNingbo Eye Hospital, Wenzhou Medical University, Ningbo, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Wet age-related macular degeneration (wAMD) is a vision-threatening eye disease worldwide. The amplitude of low-frequency fluctuation (ALFF) method was used to observe changes in spontaneous brain activity, which may help to investigate the underlying pathological mechanism of AMD. Methods: Eighteen patients with wAMD and 18 age- and gender-matched healthy controls (HCs) were recruited. The ALFF method was used on each subject and mean ALFF values were compared between groups. The receiver operating characteristic (ROC) curve was used to compare the two groups. Results: ALFF values in the temporal lobe and limbic lobe/parahippocampal gyrus were significantly higher than controls, while values in the postcentral gyrus were significantly lower. The under the curve of the ROC (AUC) of the three regions shows high accuracy of the diagnosis. Conclusion: The abnormal spontaneous brain activity of patients with AMD suggests scope for the use of ALFF in the diagnosis or prognosis in AMD.

Indexed as

age-related macular degenerationfunctional magnetic resonance imagingresting brain activityspontaneous brain activitythe amplitude of low-frequency fluctuation

Identifiers

PMID39911676
PMCPMC11794247

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