ArticleInfection and drug resistance2025
PCT/ALB Ratio in Initial Three days for the Prediction of Secondary Infection in Septic Patients.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Immunomodulatory Roles and Clinical Significance of GZMM and DDX24 in Sepsis: A Multiomics Integrative Analysis With Experimental Validation.Human mutation · 2026Article
- Routine Laboratory Tests Predict 72-h Fatality in Patients With D-Dimer Levels ≥ 2 μg/mL: A Retrospective Cohort Study Comparing Statistical and Machine Learning Models.Journal of clinical laboratory analysis · 2025Article
- Exploring the association between dexmedetomidine and all-cause mortality in mechanically ventilated patients with sepsis through propensity score matching analysis and machine learning algorithms: a MIMIC-IV retrospective study.Frontiers in cellular and infection microbiology · 2025Article
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Authors and funding
11 authors.
Funding
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Abstract
Background: Procalcitonin (PCT) to albumin (ALB) ratio (PAR) in initial three days is a rapidly available indicator to assess the prognosis of patients with sepsis. This study aims to explore the correlation between changes in PAR during the initial 72 hours and the incidence of secondary infections. Methods: A total of 147 patients with sepsis were included in this study. Patients divided into secondary infection and without secondary infection group, according to whether they had secondary infection. PAR was calculated as serum PCT (ng/mL)/ALB (mg/mL). All statistical analyses were performed using the statistical package SPSS 20.0. Results: Compared with the without secondary infection group, the median APACHE II (22[17-30] vs 16[11-25]; p=0.009) were significantly higher in the secondary infection group. And the median ΔPCT/ALB adm-72h (0.10[0.02-0.48] vs 0.17[0.03-0.65]; p=0.011) were significantly lower in the secondary infection group. On multiple logistic regression, lower ΔPCT/ALB adm-72h was independently associated with the secondary infection. Decreasing quartile of ΔPCT/ALB adm-72h was statistically significantly associated with secondary infection, particularly among survivors. Conclusion: The decline in the PCT/ALB ratio over the initial 72 hours of the acute phase of sepsis serves as an association for the onset of secondary infections during a septic patient's hospitalization.
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