Evidence map›Paper›PMID 39911547›Full record

ArticleRSC advances2025

Proof of concept for brain organoid-on-a-chip to create multiple domains in forebrain organoids.

Yuan-Chen Tsai, Hajime Ozaki, Ango Morikawa, Kaori Shiraiwa, Andy Prosvey Pin, Aya Galal Salem, Kenneth Akady Phommahasay, Bret Kiyoshi Sugita, Christine Hein Vu, Saba Mamoun Hammad and 2 more

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Organoids for disease modeling and treatment: state-of-the-art.Experimental hematology & oncology · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yuan-Chen TsaiDepartment of Anatomy and Neurobiology, University of California Irvine CA 92697 USA momokow@uci.edu.ORCID https://orcid.org/0000-0001-5250-0646
Hajime OzakiDepartment of Anatomy and Neurobiology, University of California Irvine CA 92697 USA momokow@uci.edu.ORCID https://orcid.org/0009-0000-5940-2096
Ango MorikawaInstitute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University Institute for Advanced Study Yoshida-Ushinomiya-cho, Sakyo-ku Kyoto 606-8501 Japan kamei.kenichiro.7r@kyoto-u.ac.jp.
Kaori ShiraiwaDepartment of Anatomy and Neurobiology, University of California Irvine CA 92697 USA momokow@uci.edu.
Andy Prosvey PinDepartment of Anatomy and Neurobiology, University of California Irvine CA 92697 USA momokow@uci.edu.
Aya Galal SalemDepartment of Anatomy and Neurobiology, University of California Irvine CA 92697 USA momokow@uci.edu.
Kenneth Akady PhommahasayDepartment of Anatomy and Neurobiology, University of California Irvine CA 92697 USA momokow@uci.edu.
Bret Kiyoshi SugitaDepartment of Anatomy and Neurobiology, University of California Irvine CA 92697 USA momokow@uci.edu.
Christine Hein VuDepartment of Anatomy and Neurobiology, University of California Irvine CA 92697 USA momokow@uci.edu.ORCID https://orcid.org/0000-0001-8068-9183
Saba Mamoun HammadPrograms of Biology and Bioengineering, Divisions of Science and Engineering, New York University Abu Dhabi Abu Dhabi UAE.
Ken-Ichiro KameiInstitute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University Institute for Advanced Study Yoshida-Ushinomiya-cho, Sakyo-ku Kyoto 606-8501 Japan kamei.kenichiro.7r@kyoto-u.ac.jp.ORCID https://orcid.org/0000-0003-2948-3264
Momoko WatanabeDepartment of Anatomy and Neurobiology, University of California Irvine CA 92697 USA momokow@uci.edu.ORCID https://orcid.org/0000-0001-5014-2849

Funding

Human cerebral organoids as a model system for neural development and diseaseR00HD096105 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WATANABE, MOMOKO · 2020 to 2022
$737k
NICHD NIH HHS R00 HD096105
6 · The paper itself

Abstract

Brain organoids are three-dimensionally reconstructed brain tissue derived from pluripotent stem cells

Identifiers

PMID39911547
PMCPMC11797153

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.