Evidence map›Paper›PMID 39911537›Full record

ArticleBiological psychiatry global open science2025

Neuron-Specific Glycine Metabolism Links Transfer RNA Epitranscriptomic Regulation to Complex Behaviors.

Jennifer Blaze, Viviana Dolores Evans, Jessica Abigail Feria Pliego, Petr Unichenko, Behnam Javidfar, Soeren Heissel, Hanan Alwaseem, Zachary Pennington, Denise Cai, Henrik Molina and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jennifer BlazeDepartment of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Viviana Dolores EvansDepartment of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Jessica Abigail Feria PliegoInstitute of Cellular Neurosciences, University of Bonn, Bonn, Germany.
Petr UnichenkoInstitute of Cellular Neurosciences, University of Bonn, Bonn, Germany.
Behnam JavidfarDepartment of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Soeren HeisselProteomics Resource Center, The Rockefeller University, New York, New York.
Hanan AlwaseemProteomics Resource Center, The Rockefeller University, New York, New York.
Zachary PenningtonDepartment of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Denise CaiDepartment of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Henrik MolinaProteomics Resource Center, The Rockefeller University, New York, New York.
Christian HennebergerInstitute of Cellular Neurosciences, University of Bonn, Bonn, Germany.
Schahram AkbarianDepartment of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Funding

Circuit Mechanisms of Retrospective Memory-LinkingR01MH120162 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Denise Jade Cai · 2020 to 2026
$3.9M
Modeling HIV Microglia-Associated Infection and Inflammation in a Chimeric Mouse BrainR01DA054526 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM, CHEN, BENJAMIN K · 2021 to 2025
$3.7M
Cell-lineage specific epigenomic determinants of HIV latency in humanized mouse brain and bloodR01MH134319 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Schahram Akbarian, BENJAMIN K CHEN · 2023 to 2026
$2.9M
NIDA NIH HHS R01 DA054526NIMH NIH HHS R01 MH120162NIMH NIH HHS R01 MH134319
6 · The paper itself

Abstract

Background: The presence of treatment resistance in neuropsychiatric disease suggests that novel mechanism-based discoveries and therapies could benefit the field, with a viable candidate being transfer RNA (tRNA) epitranscriptomics. Methods: To link specific molecular alterations resulting from neuronal Results: Increased motivated escape behaviors were specifically observed in mice with neuron-specific ablation of Conclusions: Alterations in neuronal glycine metabolism, resulting from targeted ablation of the glycine cleavage system or disruption of the tRNA regulome, elicit changes in complex behaviors in mice relevant for neuropsychiatric phenotypes.

Indexed as

Cell metabolismEpitranscriptomeGlycineNeuropsychiatrictRNAs

Identifiers

PMID39911537
PMCPMC11794161

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.