Evidence map›Paper›PMID 39911518›Full record

ArticleJournal of the Endocrine Society2025

Hypothalamic Estrogen Receptor α Is Essential for Female Marmoset Sexual Behavior Without Protecting From Obesity.

Marissa Kraynak, Molly M Willging, Daniel J Uhlrich, Robert A Shapiro, Matthew T Flowers, Karen A Manning, Sara D John, Samantha M Williams, Lukas J Henjum, Rebecca C Marrah and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Marissa KraynakWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.ORCID https://orcid.org/0000-0001-8612-401X
Molly M WillgingWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.ORCID https://orcid.org/0000-0002-2295-5102
Daniel J UhlrichDepartment of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705, USA.
Robert A ShapiroDepartment of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705, USA.
Matthew T FlowersDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID https://orcid.org/0009-0000-5089-5410
Karen A ManningDepartment of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705, USA.
Sara D JohnDepartment of Radiology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Samantha M WilliamsWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Lukas J HenjumWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Rebecca C MarrahWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Hannah R YohnkWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Carter B BergWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Kevin BrunnerWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Ricki J ColmanWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.ORCID https://orcid.org/0000-0001-9706-0525
Andrew L AlexanderDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA.
David H AbbottWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.ORCID https://orcid.org/0000-0002-8249-263X
Jon E LevineWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.ORCID https://orcid.org/0000-0003-4177-6406

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Role of Androgen Excess in Provoking Oxidative Stress in FemalesP50HD044405 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DUNAIF, ANDREA E · 2002 to 2017
$17.2M
Training & Education to Advance Minorities in Science (TEAM-Science)R25GM083252 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BIRD, IAN M. · 2008 to 2021
$8.5M
Endocrinology-Reproductive Physiology Training GrantT32HD041921 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI BIRD, IAN M. · 2004 to 2022
$3.0M
Whole exome analyses in naturally occurring hyperandrogenic female monkeysR21HD102172 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI ABBOTT, DAVID H, LEVINE, JON E · 2020 to 2021
$400k
NICHD NIH HHS P50 HD044405NICHD NIH HHS R21 HD102172NICHD NIH HHS T32 HD041921NIGMS NIH HHS R25 GM083252NIH HHS P51 OD011106
6 · The paper itself

Abstract

Context: Estrogen receptor α (ERα) in the ventromedial (VMN) and arcuate (ARC) nuclei of female rodent mediobasal hypothalami (MBHs) provides a crucial molecular gateway facilitating estradiol (E Objective: We hypothesized that knockdown (KD) of ERα expression in the hypothalamic VMN and ARC of female marmosets would diminish sexual receptivity, while simultaneously disrupting gonadotropic and metabolic homeostasis. Methods: We ovariectomized (OVX) adult female marmosets of comparable age and weight, immediately replaced E Results: ERα expression was significantly diminished in the VMN and ARC, but not the preoptic area (POA), of ERαKD females coincident with elimination of timely female sexual responses, more than 80% loss of female receptivity, modestly elevated gonadotropin levels, hyperglycemia, and diminished calorie consumption. Density and intensity of ERα-expressing cells in the VMN correlated positively with female sexual receptivity and calorie consumption, negatively with timeliness of female sexual responses, and in the ARC, correlated negatively with calorie consumption. Conclusion: ERα activation in the female NHP MBH is critically important for female sexual behavior and modestly contributes to gonadotropic and metabolic control.

Indexed as

arcuate nucleusdiet-induced obesityfemale sexual dysfunctionhyperglycemiahypergonadotropismventromedial nucleus

Identifiers

PMID39911518
PMCPMC11795203

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.