Evidence map›Paper›PMID 39911440›Full record

ArticleHeliyon2025

Report of joint hypermobility in malignant hyperthermia susceptible patients: Observational study with a case-control descriptive design.

Rita Ccs Santos, Larissa Fcdms Lima, Pâmela V Andrade, Joilson M Santos, Leonardo Galleni, Antonio Fr Junior, Lucas S Souza, Beny Schmidt, Acary Sb Oliveira, José Lg Amaral and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rita Ccs SantosMH Diagnosis and Investigation Study Centre (CEDHIMA: Centro de Estudo, Diagnóstico e Investigação de Hipertermia Maligna) - Anesthesiology, Pain and Intensive Therapy Department - Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Larissa Fcdms LimaMH Diagnosis and Investigation Study Centre (CEDHIMA: Centro de Estudo, Diagnóstico e Investigação de Hipertermia Maligna) - Anesthesiology, Pain and Intensive Therapy Department - Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Pâmela V AndradeMH Diagnosis and Investigation Study Centre (CEDHIMA: Centro de Estudo, Diagnóstico e Investigação de Hipertermia Maligna) - Anesthesiology, Pain and Intensive Therapy Department - Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Joilson M SantosMH Diagnosis and Investigation Study Centre (CEDHIMA: Centro de Estudo, Diagnóstico e Investigação de Hipertermia Maligna) - Anesthesiology, Pain and Intensive Therapy Department - Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Leonardo GalleniBioscience Institute, Human Genome and Stem Cells Research Center - University of São Paulo, São Paulo, SP, Brazil.
Antonio Fr JuniorBioscience Institute, Human Genome and Stem Cells Research Center - University of São Paulo, São Paulo, SP, Brazil.
Lucas S SouzaBioscience Institute, Human Genome and Stem Cells Research Center - University of São Paulo, São Paulo, SP, Brazil.
Beny SchmidtDepartment of Pathology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Acary Sb OliveiraDepartment of Neurology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
José Lg AmaralMH Diagnosis and Investigation Study Centre (CEDHIMA: Centro de Estudo, Diagnóstico e Investigação de Hipertermia Maligna) - Anesthesiology, Pain and Intensive Therapy Department - Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Mariz VainzofBioscience Institute, Human Genome and Stem Cells Research Center - University of São Paulo, São Paulo, SP, Brazil.
Helga Ca SilvaMH Diagnosis and Investigation Study Centre (CEDHIMA: Centro de Estudo, Diagnóstico e Investigação de Hipertermia Maligna) - Anesthesiology, Pain and Intensive Therapy Department - Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hypermobility is the capacity to perform joint movements in amplitudes greater than normal. Hypermobility is present in nearly 100 % of congenital myopathy central core disease (CCD) patients but is sporadically described in the allelic disease malignant hyperthermia (MH). Our objective was to investigate the frequency/characteristics of hypermobility in MH susceptible patients as compared to a control group, aiming the identification of correlations between hypermobility and demographic/clinical findings in MH patients. Methods: We recruited 26 MH patients (MH history, positive Results: Bulbena score indicative of hypermobility was significantly more frequent in MH than in the control group (50 % versus 13 %, relative risk 2.06 (95%CI 1.27-3.35), chi-square test, p < .01). Goniometric assessment revealed significantly greater range of motion of mostly proximal movements in MH versus control groups. In the MH group, there was no correlation of the Bulbena score with age, sex, clinical complaints of myalgia/cramps, CK levels, IVCT result, or degree of contracture after caffeine or halothane. Conclusions: It is possible that predominantly proximal hypermobility is part of a clinical spectrum associated with

Indexed as

Central core diseaseGoniometryJoint instabilityMalignant hyperthermiaMyopathyRyanodine receptor gene

Identifiers

PMID39911440
PMCPMC11795088

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.