Evidence map›Paper›PMID 39911218›Full record

ArticleFrontiers in public health2025

Associations of combined exposure to selected metal mixtures with thyroid hormones in children: a cross-sectional study in China.

Yuhan Cao, Shiting Xiang, Yuwei Du, Meiling Chen, Rumeng Xue, Qi Li, Jun Qiu, Yanying Duan

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Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yuhan Cao *Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, China.
Shiting Xiang *Hunan Children's Research Institute (HCRI), The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.
Yuwei DuDepartment of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, China.
Meiling ChenDepartment of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, China.
Rumeng XueDepartment of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, China.
Qi LiHunan Institute for Drug Control, Changsha, China.
Jun QiuHunan Children's Research Institute (HCRI), The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.
Yanying DuanDepartment of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Exposure to several metal elements has been found to be associated with thyroid hormone homeostasis. However, evidence for combined exposure is inconclusive, especially for children. Objective: To examine the individual and joint effects of blood metal elements on thyroid hormones in children. Methods: A total of 12,470 children aged 0-14 were collected from January 2018 to December 2021 in Hunan Children's Hospital. The concentrations of lead (Pb), iron (Fe), calcium (Ca), copper (Cu), zinc (Zn) and magnesium (Mg) in blood were detected via atomic absorption spectrometry (AAS). The levels of thyroid stimulating hormone (TSH), triiodothyronine (TT3, FT3) and total and free thyroxine (TT4, FT4) were measured by electrochemiluminescence immunoassay (ECLIA). Generalized linear regression (GLR) model and Quantile-based g-computation (QGC) were employed to estimate the association between metal exposure and thyroid hormone homeostasis. Results: GLR model showed that a unit increase in ln-transformed Fe was associated with increases in TT3 (β = 0.163; Conclusions: The combined metal exposure was associated with increased levels of TT3, TT4, and FT3 in children and Fe appeared to be the major contributor. Further studies are warranted to confirm our findings and elucidate the underlying mechanisms.

Indexed as

Environmental ExposureMetalsThyroid HormonesAdolescentChildChild, PreschoolChinaCross-Sectional StudiesFemaleHumansInfantInfant, NewbornMaleMetalsThyroid Hormoneschildrenmetalsmixture exposurequantile-based g-computation (QGC)thyroid hormones

Identifiers

PMID39911218
PMCPMC11794202

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.