Evidence map›Paper›PMID 39911165›Full record

ArticleStats2025

Bidirectional f-Divergence-Based Deep Generative Method for Imputing Missing Values in Time-Series Data.

Wen-Shan Liu, Tong Si, Aldas Kriauciunas, Marcus Snell, Haijun Gong

Abstract read
In one paragraph

Article in Stats, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Blue Noise-based Generative Models for the Imputation of Time-series Data.International Conference on Information Science and Technology. International Conference on Information Science and Technology · 2025
    Article
  3. Gene Regulatory Network Inference from Pseudotime-Ordered scRNA-seq Data via Time-Lagged Divergence Measures.Bioinformatics research and applications : ... international symposium, ISBRA ... proceedings. ISBRA (Conference) · 2025
    Article
  4. Article
  5. Time-Varying Gene Regulatory Networks Inference Using KL Divergence from Single Cell Data.Proceedings of the ... International Conference on Bioinformatics and Biomedical Technology · 2025
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wen-Shan LiuDepartment of Health and Clinical Outcomes Research, Saint Louis University, St. Louis, MO 63103, USA.ORCID 0009-0003-3962-3088
Tong SiDepartment of Mathematics and Computer Science, Culver-Stockton College, Canton, MO 63435, USA.ORCID 0000-0002-0430-7283
Aldas KriauciunasDepartment of Mathematics and Statistics, Saint Louis University, St. Louis, MO 63103, USA.
Marcus SnellDepartment of Mathematics and Statistics, Saint Louis University, St. Louis, MO 63103, USA.
Haijun GongDepartment of Mathematics and Statistics, Saint Louis University, St. Louis, MO 63103, USA.ORCID 0000-0003-1666-1674

Funding

Novel Systems Biology Methods for the Cell-type-specific Regulatory Networks Reconstruction from scRNA-seq DataR15GM148915 · NIGMS · SAINT LOUIS UNIVERSITY · PI GONG, HAIJUN · 2022 to 2023
$545k
NIGMS NIH HHS R15 GM148915
6 · The paper itself

Abstract

Imputing missing values in high-dimensional time-series data remains a significant challenge in statistics and machine learning. Although various methods have been proposed in recent years, many struggle with limitations and reduced accuracy, particularly when the missing rate is high. In this work, we present a novel f-divergence-based bidirectional generative adversarial imputation network, tf-BiGAIN, designed to address these challenges in time-series data imputation. Unlike traditional imputation methods, tf-BiGAIN employs a generative model to synthesize missing values without relying on distributional assumptions. The imputation process is achieved by training two neural networks, implemented using bidirectional modified gated recurrent units, with f-divergence serving as the objective function to guide optimization. Compared to existing deep learning-based methods, tf-BiGAIN introduces two key innovations. First, the use of f-divergence provides a flexible and adaptable framework for optimizing the model across diverse imputation tasks, enhancing its versatility. Second, the use of bidirectional gated recurrent units allows the model to leverage both forward and backward temporal information. This bidirectional approach enables the model to effectively capture dependencies from both past and future observations, enhancing its imputation accuracy and robustness. We applied tf-BiGAIN to analyze two real-world time-series datasets, demonstrating its superior performance in imputing missing values and outperforming existing methods in terms of accuracy and robustness.

Indexed as

bidirectional gated recurrent unitf-divergencegenerative adversarial networkmissing value imputationtime series

Identifiers

PMID39911165
PMCPMC11793919

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.