Evidence map›Paper›PMID 39911134›Full record

ArticleTechnical innovations & patient support in radiation oncology2025

Geometric and dosimetric evaluation of CTV contour adaptations by radiation therapists for adaptive prostate radiotherapy on a 0.35 T MR-Linac.

Boaz Kalkhoven, Marjolein N Hilberts, Melissa A L Verdonk, An-Sofie E Verrijssen, Peter-Paul G van der Toorn, Tom C G Budiharto, Patricia F C Bronius, Diana Geerts, Coen W Hurkmans, Shyama U Tetar and 1 more

Abstract read
In one paragraph

Article in Technical innovations & patient support in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Boaz KalkhovenDept of Radiation Oncology, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, the Netherlands.
Marjolein N HilbertsDept of Radiation Oncology, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, the Netherlands.
Melissa A L VerdonkDept of Radiation Oncology, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, the Netherlands.
An-Sofie E VerrijssenDept of Radiation Oncology, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, the Netherlands.
Peter-Paul G van der ToornDept of Radiation Oncology, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, the Netherlands.
Tom C G BudihartoDept of Radiation Oncology, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, the Netherlands.
Patricia F C BroniusDept of Radiation Oncology, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, the Netherlands.
Diana GeertsDept of Radiation Oncology, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, the Netherlands.
Coen W HurkmansDept of Radiation Oncology, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, the Netherlands.
Shyama U TetarDept of Radiation Oncology, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, the Netherlands.
Rob H N TijssenDept of Radiation Oncology, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & purpose: Magnetic resonance guided adaptive radiotherapy (MRgART) enables hypofractionated prostate radiotherapy by daily contour adaptation. The MRgART workflow, however, is labour intensive and in many institutes still requires the presence of the radiation oncologist (RO). Transferring the online contour adaptation task to the radiation therapist (RTT) will release the clinician from attending each treatment fraction making MRgRT more efficient and cost effective. In this study we investigate the viability of RTT-led prostate MRgART on a low-field MR-linac, by assessing the interobserver variations of RTT- and RO-generated CTV contour adaptations as well as the resulting dosimetric effects. Materials & methods: Four RTTs and four ROs performed CTV contour adaptations on first fraction data in ten patients. Delineations were compared against a gold standard contour using target volume, Dice similarity coefficient (DSC), and 95th percentile Hausdorff distance. In addition, a dosimetric evaluation was performed on all first fractions by performing plan adaptations based on all RTT contour adaptation and comparing these to the clinically delivered plan. Finally, a full-treatment simulation was performed in four patients to investigate the dosimetric effects of the RTTs' contour adaptations throughout an entire treatment. Results: RTTs with no experience in prostate delineation prior to this study spent more time on CTV contour adaptations. The geometric and dosimetric analyses, however, showed no statistically significant differences between both groups. Conclusions: This study confirmed that RTTs perform similarly to ROs in carrying out online contour adaptations. These results indicate the feasibility of initiating a transition in contour adaptation tasks from ROs to RTTs.

Indexed as

Contour adaptationMR-LinacProstate radiotherapyRadiation therapist

Identifiers

PMID39911134
PMCPMC11795812

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.