ArticleMacromolecular bioscience2025
Development and Degradation Study of PLA-Based Medical Implant Markers for Magnetic Particle Imaging.
Article in Macromolecular bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Preparation and Characterization of Coated ZnFeACS omega · 2026Article
- Simple-to-Fabricate and Water-Stable Instrument Markers for Preclinical Magnetic Particle Imaging and Magnetic Resonance Imaging.Medical devices (Auckland, N.Z.) · 2026Article
- Development and Degradation Study of PLA-Based Medical Implant Markers for Magnetic Particle Imaging.Macromolecular bioscience · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Magnetic particle imaging (MPI) is a promising imaging modality nearing clinical introduction. MPI's tracer-based principle allows for highly sensitive background-free imaging. Potential clinical applications include cardiovascular imaging and endovascular interventions. In principle, medical instruments are invisible in MPI due to the missing signal generation. Therefore, permanent marking technologies have been introduced. Additionally, temporary markers are of interest for follow-up examinations after stent implantation to prevent artifacts during postinterventional stent lumen quantification. Consequently, medical instrument markers for MPI, based on biodegradable polylactic acid (PLA) and superparamagnetic iron-oxide nanoparticles (SPIONs), are developed in this study. To investigate the markers, signal characteristics and degradation over time are studied for 28 d in a water bath at 37 °C. The samples are analyzed using a scale, micro-CT, microscopy, magnetic particle spectroscopy (MPS), MPI, and vibrating sample magnetometry (VSM). A continuous mass decrease is detected (≈90% after 28 d), while MPS and MPI data show no loss of signal. VSM confirms that the markers' mass reduction can be accounted for the degradation of PLA, while the SPIONs hardly detach from the coating. The introduced marking technology, with its degradation characteristics and signal behavior, is the basis for a variety of anticipated medical application scenarios.
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Registered trials
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