Evidence map›Paper›PMID 39910966›Full record

ArticleJournal of animal science2025

Genetic parameter estimates of liver abscesses in feedlot beef cattle.

Melanie K Hess, Rebecca L McDermott, Galen E Erickson, Matthew L Spangler

Abstract read
In one paragraph

Article in Journal of animal science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Melanie K HessDepartment of Animal Science, University of Nebraska - Lincoln, Lincoln, NE 68503.
Rebecca L McDermottDepartment of Animal Science, University of Nebraska - Lincoln, Lincoln, NE 68503.
Galen E EricksonDepartment of Animal Science, University of Nebraska - Lincoln, Lincoln, NE 68503.ORCID 0000-0001-7673-9037
Matthew L SpanglerDepartment of Animal Science, University of Nebraska - Lincoln, Lincoln, NE 68503.ORCID 0000-0001-5184-501X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The primary reason livers are condemned is due to abscesses, which are visible lesions detected on the liver during routine harvest of the animal. Condemned livers are deemed not fit for human consumption, and result in over $15M in lost income to the U.S. beef industry each year. Liver scoring is a 4-level measurement of abscess severity: 0 (no abscesses), A- (mild: 1 to 2 small abscesses), A (moderate: 2 to 4 active abscesses), and A+ (severe: 1 or more large, active abscesses). We quantified the degree to which known sources of variation, including genomic differences among animals, contribute to the incidence of liver abscesses in 1,747 feedlot cattle fed a range of diets. Diets were grouped based on corn type (dry-rolled corn [DRC], high-moisture corn [HMC], DRC/HMC or steam-flaked corn [SFC]) and byproduct (none, modified distillers grains plus solubles [MDGS], and Sweet Bran fed at 20%, 35%, or 40%). A common set of SNP (n = 44,666) from the Illumina BovineSNP50 v2 and GGP Bovine 100K were used for genomic analyses. The posterior mean (posterior standard deviation) heritability estimate of liver score was 0.10 (0.05). Within-diet heritability estimates were not significantly different from zero but ranged from 0.02 (0.02) (MDGS) to 0.29 (0.32) (Sweet Bran fed at 35%). A BayesB Genome-Wide Association Study (GWAS) with showed that liver score is a very polygenic trait with no large effect quantitative trait loci (QTL) segregating in this population. The genetic and phenotypic correlations of liver score with hot carcass weight, 12th rib fat, longissimus muscle area, or marbling score were not significantly different from zero. Results from the current study show that genomic selection for reduced liver score could be a useful tool to reduce the occurrence of liver abscesses in feedlot cattle, alongside current mitigation strategies; however, more data are needed to gain a better understanding of the genetic basis of liver score, as well as the relationship between liver score and other economically relevant traits, and potential genetic × diet interactions.

Indexed as

Cattle DiseasesLiver AbscessAnimal FeedAnimalsCattleDietMalePolymorphism, Single Nucleotidebeef cattlecarcass traitsGenome-Wide Association Studyheritabilityliver abscessliver score

Identifiers

PMID39910966
PMCPMC11897889

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.