Evidence map›Paper›PMID 39910910›Full record

Observational studyRespirology (Carlton, Vic.)2025

Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia.

Yunqing Zhu, Yongbing Lan, Jun Lv, Dianjianyi Sun, Pei Pei, Ling Yang, Iona Y Millwood, Robin G Walters, Yiping Chen, Huaidong Du and 8 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Respirology (Carlton, Vic.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Yunqing ZhuDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.
Yongbing LanDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.
Jun LvDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.ORCID 0000-0001-7916-3870
Dianjianyi SunDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.
Pei PeiPeking University Center for Public Health and Epidemic Preparedness & Response, Beijing, China.
Ling YangMedical Research Council Population Health Research Unit, University of Oxford, Oxford, UK.
Iona Y MillwoodMedical Research Council Population Health Research Unit, University of Oxford, Oxford, UK.
Robin G WaltersMedical Research Council Population Health Research Unit, University of Oxford, Oxford, UK.
Yiping ChenMedical Research Council Population Health Research Unit, University of Oxford, Oxford, UK.
Huaidong DuMedical Research Council Population Health Research Unit, University of Oxford, Oxford, UK.
Jian WangNCDs Prevention and Control Department, Pengzhou CDC, Pengzhou, Sichuan, China.
Xiaoming YangClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Rebecca StevensClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Junshi ChenChina National Center for Food Safety Risk Assessment, Beijing, China.
Zhengming ChenClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Liming LiDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.
Canqing YuDepartment of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.ORCID 0000-0002-0019-0014
China Kadoorie Biobank Collaborative Group

Funding

British Heart Foundation CH/1996001/9454Cancer Research UK 16896Cancer Research UK A29186Cancer Research UK C16077/A29186Cancer Research UK C500/A16896Kadoorie Charitable Foundation in Hong KongMedical Research Council MC_U137686851Medical Research Council MC_UU_00017/1Medical Research Council MC_UU_12026/2Ministry of Science and Technology of the People's Republic of China 2011BAI09B01National Key Research and Development Program of China 2016YFC0900500National Natural Science Foundation of China 81390540National Natural Science Foundation of China 81941018National Natural Science Foundation of China 82192900National Natural Science Foundation of China 82192901National Natural Science Foundation of China 82192904National Natural Science Foundation of China 82388102National Natural Science Foundation of China 91846303Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0510100Wellcome Trust 088158Wellcome Trust 088158/Z/09/ZWellcome Trust 104085Wellcome Trust 104085/Z/14/ZWellcome Trust 202922Wellcome Trust 202922/Z/16/ZWellcome Trust 212946Wellcome Trust 212946/Z/18/Z
6 · The paper itself

Abstract

BACKGROUND AND

objectivePrevious observational studies reported a complex relationship between snoring and coronary artery disease (CAD). We aimed to estimate the causal associations between snoring and CAD among East Asian people, and the effects independent of BMI.

methodsBased on 497,250 adults from China Kadoorie Biobank (CKB), we performed a conventional prospective analysis between snoring and CAD outcomes, using the multivariable Cox regression. We also leveraged genome-wide association (GWAS) summary statistics of snoring and BMI from CKB (n = 100,626, 47,208 snorers) and CAD outcomes from Biobank of Japan (BBJ, 5891-25,892 cases, 142,336-168,186 controls). Single-variable and multivariable two-sample bi-directional Mendelian randomization (MR) analyses were performed.

resultsDuring a median follow-up of 12.32 years, 48,997 participants developed CAD. Snoring and habitual snoring were associated with incident CAD and myocardial infarction (MI), habitual snoring was also associated with stable angina pectoris (SAP). The HRs (95% CIs) of habitual snoring were 1.06 (1.04, 1.08), 1.06 (1.04, 1.08) and 1.14 (1.03, 1.25). The associations remained among non-adiposity participants. Genetically predicted habitual snoring was associated with CAD and MI, the corresponding IVW-ORs (95% CIs) were 1.09 (1.005, 1.19) and 1.15 (1.05, 1.25). Further adjusted BMI, habitual snoring retained independent effects on MI and CAD, and showed impact on SAP (1.09 [1.01, 1.17]). No reverse associations were observed between CADs on snoring traits.

conclusionHabitual snoring elevated the risks of total CAD, MI and SAP. The causal associations were independent of BMI. These findings indicated that snoring intervention might contribute to the decrease of CAD risk among Asians.

Indexed as

Body Mass IndexCoronary Artery DiseaseSnoringAdultAgedChinaEast Asian PeopleFemaleGenome-Wide Association StudyHumansJapanMaleMendelian Randomization AnalysisMiddle AgedProspective StudiesRisk Factorsbody mass indexcoronary artery diseasemendelian randomizationsnoring

Identifiers

PMID39910910
PMCPMC7617645

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.