Evidence map›Paper›PMID 39910909›Full record

ReviewExperimental physiology2025

Turning over new ideas in human skeletal muscle proteostasis: What do we know and where to from here?

Changhyun Lim, James McKendry, Matthew Lees, Philip J Atherton, Nicholas A Burd, Andrew M Holwerda, Luc J C van Loon, Chris McGlory, Cameron J Mitchell, Kenneth Smith and 3 more

Abstract readReview
In one paragraph

Review in Experimental physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Changhyun LimExercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0002-5437-8063
James McKendryExercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Matthew LeesExercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Philip J AthertonMRC/ARUK Centre for Musculoskeletal Ageing Research and National Institute of Health Research, Biomedical Research Centre, School of Medicine, University of Nottingham, Derby, UK.ORCID https://orcid.org/0000-0002-7286-046X
Nicholas A BurdDepartment of Health and Kinesiology and Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Andrew M HolwerdaDepartment of Human Biology, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, the Netherlands.
Luc J C van LoonDepartment of Human Biology, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, the Netherlands.
Chris McGlorySchool of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
Cameron J MitchellFaculty of Education, School of Kinesiology, The University of British Columbia, Vancouver, BC, Canada.
Kenneth SmithMRC/ARUK Centre for Musculoskeletal Ageing Research and National Institute of Health Research, Biomedical Research Centre, School of Medicine, University of Nottingham, Derby, UK.
Daniel J WilkinsonMRC/ARUK Centre for Musculoskeletal Ageing Research and National Institute of Health Research, Biomedical Research Centre, School of Medicine, University of Nottingham, Derby, UK.
Tanner StokesExercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Stuart M PhillipsExercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0002-1956-4098

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the turnover of proteins in tissues gives information as to how external stimuli result in phenotypic change. Nowhere is such phenotypic change more conspicuous than skeletal muscle, which can be effectively remodelled by increased loading, ageing and unloading (disuse), all of which are subject to modification by nutrition and other environmental stimuli. The understanding of muscle proteome remodelling has undergone a renaissance recently with the reintroduction of deuterated water (D

Indexed as

deuterium oxidehumanphenotypeskeletal musclestable isotope tracer

Identifiers

PMID39910909
PMCPMC13394054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.