Evidence map›Paper›PMID 39910899›Full record

ArticleBrain and behavior2025

Adolescent Depression and Cognition Risk for Suicide: An Investigation of Risk Factors and Gene Environment Interactions.

Stefanie Pilkay, Devorah Halevy, Danielle Femia, Sage Malina Holland, Stephanie Heiland, Andrew M Carroll, Sarah Nunes, Tara Veerman, Leah Dudak

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PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [Relationship between family trauma, school bullying and suicidal behavior in adolescents: Regulatory effect ofBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stefanie PilkaySchool of Social Work, Syracuse University, Syracuse, New York, USA.
Devorah HalevyWurzweiler School of Social Work, Yeshiva University, New York, New York, USA.ORCID https://orcid.org/0000-0001-6575-8355
Danielle FemiaSchool of Social Work, Syracuse University, Syracuse, New York, USA.
Sage Malina HollandSchool of Social Work, Syracuse University, Syracuse, New York, USA.
Stephanie HeilandSchool of Social Work, Syracuse University, Syracuse, New York, USA.ORCID https://orcid.org/0009-0006-0272-4100
Andrew M CarrollSchool of Social Work, Syracuse University, Syracuse, New York, USA.
Sarah NunesSchool of Social Work, Syracuse University, Syracuse, New York, USA.
Tara VeermanSchool of Social Work, Centenary University, Hackettstown, New Jersey, USA.
Leah DudakSchool of Information Studies, Syraucse University, Syracuse, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrior research has been conducted to understand the connection between maternal physical health and its effects on children and adolescents. Much less research has focused on maternal mental health and gene-environmental factors that influence children's and adolescent's development. This study investigated the risk factors and gene-environment interactions in relation to maternal mental health and adolescent depression and cognition risk for suicide.

methodsThe data and sample utilized in this research were obtained from The Future of Families and Child Wellbeing Study. The cohort comprises a total of 4898 children and their corresponding caregivers, of which 1829 had complete data and were used in this study. To account for missing data, the list wise deletion approach was employed for all analyses. The variables were tested using Likert scales and/or other similar scales designed to specifically measure the variable. Hypotheses were tested with multiple regressions and bootstrapping. Multiple comparisons were controlled with the Benjamini Hochberg false discovery approach, and BH adjusted p-values are reported with each statistically significant result.

resultsThe analyses revealed four significant relationships: (1) poverty status is a strong predictor of adolescent mental health, (2) toddler attachment is affected by maternal mental health but does not interact with maternal mental health to predict adolescent mental health, (3) maternal mental health affects suspected childhood sexual abuse associations with adolescent mental health, and (4) serotonin transporter alleles (SLC6A4) exert specific effects on adolescent mental health cognitions previously linked to suicide risk.

conclusionIn summary, this study concludes that the experiential factors and genetic variation have interconnected influences on the mental well-being of children and adolescents. Therefore, interventions aimed at addressing child trauma would be enhanced by integrating a component that specifically addresses the mental well-being of mothers.

Indexed as

CognitionDepressionGene-Environment InteractionSuicideAdolescentAdultChildFemaleHumansMaleMental HealthMother-Child RelationsMothersRisk FactorsSerotonin Plasma Membrane Transport ProteinsSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, human

Identifiers

PMID39910899
PMCPMC11799590

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