ArticleBrain and behavior2025
Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSleep behaviors, defined by the total duration of sleep and chronotype, significantly influence overall health. Compromised sleep quality, which is often manifested through reduced sleep duration and the prevalence of insomnia, has been found to be associated with micronutrient deficiencies. Nonetheless, the existence of a causal relationship between micronutrient levels and sleep behaviors remains to be established.
methodsA two-sample Mendelian randomization (MR) analysis, utilizing data from genome-wide association studies (GWAS), was employed to examine the associations between 15 micronutrients (copper; calcium; carotene; folate; iron; magnesium; potassium; selenium; vitamins A, B12, B6, C, D, and E; and zinc) and various sleep behaviors, including short and long sleep durations, insomnia, and chronotype. Furthermore, multivariable MR (MVMR) analysis was performed to address potential confounding due to the interrelationships among micronutrients and to discern potential causal relationships.
resultsThe MR analysis identified a causal association between folate levels and chronotype (odds ratio [OR] = 1.09; 95% confidence interval [CI]: 1.01-1.17; p = 0.02), indicating a tendency toward morningness. Conversely, vitamin B6 (OR = 0.91; 95% CI: 0.86-0.96; p = 1.05 × 10
conclusionsElevated folate levels correlate with morning-type preferences ("morning birds"), while higher concentrations of vitamin B6 are associated with evening-type preferences ("evening owls").
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