Evidence map›Paper›PMID 39910789›Full record

ArticleTissue barriers2025

Size-selective permeation-enhancing modulation of the tight junction by receptor-binding domains of

Keisuke Tachibana, Sayaka Sugimura, Shuko Sakimura, Lin Bai, Hiroshi Aoyama, Hiroyuki Takeda, Yuki Niwa, Masahiro Nagahama, Masuo Kondoh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue barriers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Keisuke TachibanaGraduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Sayaka SugimuraGraduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Shuko SakimuraGraduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Lin BaiGraduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Hiroshi AoyamaGraduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Hiroyuki TakedaProteo-Science Center, Ehime University, Matsuyama, Ehime, Japan.
Yuki NiwaGraduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Masahiro NagahamaFaculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.
Masuo KondohGraduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modulation of claudin-based bicellular tight junction (TJ) and angulin-based tricellular TJ seals has been shown to enhance mucosal permeation of macromolecules, by using the receptor-binding fragments of

Indexed as

ADP Ribose TransferasesBacterial ToxinsClostridium perfringensEnterotoxinsTight JunctionsCaco-2 CellsHumansADP Ribose TransferasesBacterial Toxinsenterotoxin, ClostridiumEnterotoxinsiota toxin, Clostridium perfringensAbsorptionangubindin-1Caco-2 cellC-CPEepithelial cellsintestinal transportpermeability

Identifiers

PMID39910789
PMCPMC12506900

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.