ArticleJournal of cosmetic dermatology2025
Effects of Poly-L-Lactic Acid Fillers on Inflammatory Response and Collagen Synthesis in Different Animal Models.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy, Durability, and Safety of Collagen Biostimulators Based on Poly-L-Lactic Acid (PLLA) and Calcium Hydroxyapatite (CaHA) in the Face: A Systematic Review.Aesthetic plastic surgery · 2026Pooled it
- Effectiveness and Safety of a Polyvinyl Alcohol Microsphere and Hyaluronic Acid Suspension for Chin Augmentation: A Randomized Controlled Trial and Multidisciplinary Study.Aesthetic surgery journal · 2026Trial
- Injectable Particulated Human Acellular Dermal Matrix Booster for Skin Restoration: An Integrated Randomized, Split-Face, Double-Blinded Clinical Trial and Preclinical Study.International journal of molecular sciences · 2026Trial
- Long-Term In Vivo Biological Performance of PLLA-b-PEG/HA Filler.Journal of functional biomaterials · 2026Article
- Changes of Tissue Reactions on Various HA Filler Under Immune Stress Status: An In Vivo Study.Aesthetic plastic surgery · 2026Article
- Click-crosslinked nanogels integrated into 3D stem cell spheroids enhance regenerative function for swallowing muscle repair.Biomaterials · 2026Article
- Advanced Design Concepts for Shape-Memory Polymers in Biomedical Applications and Soft Robotics.Polymers · 2026Review
- Poly-L-lactic acid (PLLA) in arm contouring: a prospective and blinded trial of Rennova® Elleva and Sculptra®.Frontiers in surgery · 2026Article
- A Novel High-Safety Filler with Potential Periosteal Enhancement: In Vivo Evaluation of Cross-Linked Sodium Hyaluronate Gel with PVA Microspheres in Rat Models.Journal of cosmetic dermatology · 2025Article
- [Progress and challenges of poly (Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Review
- Poly-L-Lactic Acid Filler Increases Adipogenesis and Adiponectin in Aged Subcutaneous Tissue.Polymers · 2025Article
- Comparative Analysis of Reconstitution and Solubility of Two Poly-L-Lactic Acid Fillers for Medical Applications.Polymers · 2025Article
- Poly-lactic Acid Dermal Filler Enriched With InCubeIn vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundThe responses to poly-L-lactic acid (PLLA) filler implantation exhibit variability across various animal models. This study aimed to investigate these differences in order to identify suitable animal models for diverse experimental applications.
methodsPLLA fillers were implanted into two distinct skin layers (periosteum and subcutaneous tissue), in rabbits, guinea pigs, rats, and mice. At 1, 2, 4, and 12 weeks postimplantation, biopsy samples were collected for hematoxylin and eosin staining, Masson's trichrome staining, and enzyme-linked immunosorbent assay (ELISA) to evaluate the differential responses among the animals.
resultsAll four animal models exhibited significant inflammatory responses and collagen regeneration following PLLA injection. However, the magnitude of these responses varied across species, with guinea pigs and rabbits displaying the most pronounced inflammatory responses, whereas mice exhibited the mildest. The degree of response also differed between tissue layers, with rats and mice showing stronger inflammatory responses in the periosteum compared to the subcutaneous tissue; a phenomenon not observed in rabbits and guinea pigs. ELISA analysis revealed upregulated TNF-α, IL-12, and TGF-β expression in rats and mice at 12 weeks.
conclusionsVarying levels of tissue responses are observed following PLLA injections in different animals and within different tissue layers within a single animal. These findings suggest a careful selection of appropriate animal models is necessary for specific research objectives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.