Evidence map›Paper›PMID 39910448›Full record

ArticleBMC neuroscience2025

Platelet-rich fibrin and silver nano-particles loaded chitosan treatment for post- laminectomy epidural scar adhesions: in vivo rats study model.

Samah Fouad, Awad Rizk, Esam Mosbah, Mostafa M Nabeeh, Walaa Awadin, Ayman S Elmezayyen, Ekramy Elmorsy, Adel Zaghloul

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samah FouadMedical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.
Awad RizkDepartment of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt. awadrizk2010@mans.edu.eg.
Esam MosbahDepartment of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.
Mostafa M NabeehDepartment of Neurosurgery, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.
Walaa AwadinDepartment of Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.
Ayman S ElmezayyenPhysics Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt.
Ekramy ElmorsyCenter for Health Research, Northern Border University, Arar, Saudi Arabia. Ekramy.elmorsy@nbu.edu.sa.
Adel ZaghloulDepartment of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEpidural scar fibrosis commonly leads to functional disability and pain following spinal surgery and is a prevalent manifestation of Failed Back Surgery Syndrome (FBSS). This study aimed to evaluate the use of silver nano-articles (AgNPs) loaded on chitosan (Chi/Ag-NPs) with platelets-rich fibrin (PRF) gel for the reduction of post-laminectomy epidural scar adhesions.

methodsA total of 90 male Sprague Dawley rats (255 ± 55gm) were randomized in-to six groups, each group with 15 rats: control group, laminectomy group, PRF group, Chi/Ag-NPs group, combined treatment group (PRF + Chi/Ag-NPs), and a group to prepare PRF. Lumbar laminectomy procedures were performed between L3-L5 in all rats except the control group. After a 30-days follow-up, macroscopic examination, histological studies, and mRNA evaluation for TGFβ-1and IL-6, were conducted.

resultsData revealed that epidural scar adhesion, scaring, arachnoid involvement, dural thickness, as well as inflammation and TGFβ-1and IL-6 coding genes expression were significantly reduced in PRF group, Chi/Ag-NPs group, and combined group compared to the laminectomy group. Combined treatment showed more significant better outcomes.

conclusionThe use of PRF with Chi/Ag-NPs as nano biomaterials could be considered a combination therapy for the reduction of EF post-laminectomy in a rat model.

Indexed as

ChitosanCicatrixLaminectomyMetal NanoparticlesPlatelet-Rich FibrinSilverAnimalsDisease Models, AnimalEpidural SpaceMaleRatsRats, Sprague-DawleyTissue AdhesionsChitosanSilverEpidural scar fibrosisLaminectomyPlatelets-rich fibrinSilver nanoparticle loaded chitosan

Identifiers

PMID39910448
PMCPMC11796154

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.