ArticleNature2025
RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition.
Erratum issued Registry-linked trialAbstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07654517 (A Phase I Evaluation of the Safety and Tolerability of Pirfenidone in Idiopathic Subglottic Stenosis), which is not on this map. Cited by 58 papers.
0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT07654517 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation
A Phase I Evaluation of the Safety and Tolerability of Pirfenidone in Idiopathic Subglottic Stenosis
Who cites it
58 citing papers in PubMed.
- Collaborative functionality between three types of inflammation in idiopathic pulmonary fibrosis.Nature immunology · 2026Review
- Collagenase-Coated Polymeric Drug/siRNA Nanoparticles Overcome ECM and Regulate Metabolic Reprogramming of Fibroblasts for Alleviating Pulmonary Fibrosis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Mechanosensitive phosphorylation of NFATC4 at S213/S217 drives fibroblast-to-myofibroblast transition and fibrosis.The Journal of clinical investigation · 2026Article
- Current smoking and COPD are associated with differentiation-dependent secretory and inflammatory programs in airway basal cells.Respiratory research · 2026Article
- Leptomeningeal fibroblasts promote glioblastoma progression by regulating cerebrospinal fluid dynamics.Nature communications · 2026Article
- Cytoskeletal-nuclear control of alveolar fibroblast identity directs lung regeneration.bioRxiv : the preprint server for biology · 2026Article
- Periostin defines a pathological fibroblast program enriched in restrictive allograft syndrome.JCI insight · 2026Article
- Ellagic acid and gallic acid combination attenuates pulmonary fibrotic responses in vitro: evidence suggesting involvement of the 5-HT2B/Ca²⁺/inflammatory axis.Molecular biology reports · 2026Article
- Mesothelial Plasticity Specifies Divergent Pleural Immune Circuits that Instruct Lung Regeneration versus Degeneration.Research square · 2026Article
- Fibroblasts: a diverse population of cells balancing homeostasis, wound healing, regeneration, inflammation, fibrosis, and cancer across organs.JCI insight · 2026Review
- Altered AP-1, RUNX, and EGR chromatin dynamics drive human fibrotic lung disease.Annals of the rheumatic diseases · 2026Article
- RUNX1 is a mediator of fibrotic activation and epigenetic memory in lung fibroblasts.American journal of respiratory cell and molecular biology · 2026Article
- Bone-derived Osterix+ osteolineage cells are a source of tumor-promoting myofibroblastic cancer-associated fibroblasts in breast cancer.Nature communications · 2026Article
- Fibroblasts as regulators of lung immunity, repair and fibrosis.Nature reviews. Immunology · 2026Review
- 2025 annual review of basic and translational research advances in pulmonary fibrosis: a narrative review.Journal of thoracic disease · 2026Review
- Alveolar niche disruption and aberrant epithelial reprogramming are early hallmarks of idiopathic pulmonary fibrosis.bioRxiv : the preprint server for biology · 2026Article
- Exploring the role of RCEO in macrophage-mediated modulation of pulmonary fibrosis.Chinese medicine · 2026Article
- Pulmonary Fibrosis Beyond the Lung: Adipose Tissue as a Systemic Modifier of Fibrotic Remodeling.Diagnostics (Basel, Switzerland) · 2026Review
- The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis.Science advances · 2026Article
- Persistence of alveolar fibroblast-derived ADAMTS4+ cells in a preclinical model of delayed pulmonary fibrosis resolution.Nature communications · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
18 authors.
Yinshan FangColumbia Center for Human Development and Division of Digestive and Liver Disease, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-9249-4498
Sanny S W ChungColumbia Center for Human Development and Division of Digestive and Liver Disease, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0003-0481-4557
Le XuDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-6321-5023
Chenyi XueDivision of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-8829-7659
Xue LiuDepartment of Medicine and Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-2104-9335
Dianhua JiangDepartment of Medicine and Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-4508-3829
Rongbo LiDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-9112-9712
Yohei KorogiDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-3044-8319
Ke YuanDivision of Pulmonary Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8085-5452
Anjali SaqiDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0003-3133-9886
Hanina HibshooshDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
Yuefeng HuangDepartment of Microbiology and Immunology, Columbia University, New York, NY, USA.ORCID 0000-0002-3860-5430
Chyuan-Sheng LinDepartment of Pathology and Cell Biology and Transgenic Mouse Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.ORCID 0000-0002-6318-3743
Takeshi TakaradaDepartment of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Tatsuya TsukuiDivision of Pulmonary, Critical Care, Allergy and Sleep, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-3100-6934
Dean SheppardDivision of Pulmonary, Critical Care, Allergy and Sleep, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6277-2036
Xin SunDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA. xinsun@ucsd.edu.ORCID 0000-0001-8387-4966
Jianwen QueColumbia Center for Human Development and Division of Digestive and Liver Disease, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA. jq2240@cumc.columbia.edu.ORCID 0000-0002-6540-6701
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MRole of Surfactant Proteins in Mediating Noninfectious Inflammatory and FibroproP01HL108793 · NHLBI · DUKE UNIVERSITY · PI NOBLE, PAUL WESLEY · 2012 to 2022
$21.3MImprove Lung Regeneration Through Targeting Tuft Cells Following Viral InfectionR01HL159675 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2021 to 2024
$2.4MTargeting WNT7A Signaling in Pulmonary FibrosisR01HL172990 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Dianhua Jiang · 2024 to 2026
$2.3MVEGF/KDR Signaling in Airway Epithelial Regeneration and DiseaseR01HL152293 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2021 to 2024
$2.0MLung vascular ILC3 subpopulation in anti-bacteria immunity and vasculature regenerationR01HL177649 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Yuefeng Huang, Jianwen Que · 2025 to 2026
$1.6MPosttranscriptional modification in lung development and regenerationR01HL179522 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2025 to 2025
$769kLeica Stellaris 8 Confocal MicroscopeS10OD032447 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2022 to 2022
$652kBD Biosciences InfluxS10OD020056 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2015 to 2015
$600kBecton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413kNCI NIH HHS P30 CA013696NCRR NIH HHS S10 RR027050NHLBI NIH HHS P01 HL108793NHLBI NIH HHS R01 HL152293NHLBI NIH HHS R01 HL159675NHLBI NIH HHS R01 HL172990NHLBI NIH HHS R01 HL177649NHLBI NIH HHS R01 HL179522NIH HHS S10 OD020056NIH HHS S10 OD032447
Abstract
A hallmark of pulmonary fibrosis is the aberrant activation of lung fibroblasts into pathological fibroblasts that produce excessive extracellular matrix
Indexed as
Core Binding Factor Alpha 1 SubunitFibroblastsPulmonary AlveoliPulmonary FibrosisAnimalsDisease Models, AnimalExtracellular MatrixFemaleMaleMiceCore Binding Factor Alpha 1 SubunitRunx2 protein, mouse
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT07654517ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.