ArticleNature2025
A comprehensive spatio-cellular map of the human hypothalamus.
Erratum issuedAbstract read
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers.
0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed.
- Genome-wide mapping of common and rare variant effects on adiposity across childhood.Nature genetics · 2026Article
- A single-nuclei multiomics resource across four brain regions prioritises human neural cell types influencing brain-related traits.bioRxiv : the preprint server for biology · 2026Article
- Autophagy in hypothalamic POMC and AgRP neurons: mechanisms and therapeutic implications for obesity.International journal of obesity (2005) · 2026Review
- The causes of cachexia: key signals and the brain.Nature reviews. Endocrinology · 2026Review
- Progressive hypothalamic neuroinflammation in ovariectomized mice parallels aging-related transcriptomic changes in the female human hypothalamus.JCI insight · 2026Article
- Review
- Genetic Determinants of Macronutrient Intake Are Associated With Specific Food Intake in Youth: A Cohort Study Across Childhood and Adolescence.Diabetes care · 2026Article
- Amylin: A Multi-Functional Pancreatic Hormone-A Review.Diabetes, obesity & metabolism · 2026Review
- Higher semaglutide dose is associated with lower neuropsychiatric event incidence independent of weight loss.npj metabolic health and disease · 2026Article
- Single-cell profiling identifies obesity-disrupted brain glucose sensing.Nature communications · 2026Article
- Hypothalamic neurovascular and extracellular matrix remodeling: Cellular niche orchestration of immune-metabolic adaptation to nutritional stress.Reviews in endocrine & metabolic disorders · 2026Review
- Transcriptome profiling of human hypothalamic agouti-related protein and proopiomelanocortin neurons regulating energy homeostasis.Nature communications · 2026Article
- A single-nucleus multiomic study of preoptic area cells in prepubertal control vs prenatally androgenized female mice.Endocrinology · 2026Article
- Cold sensing and the parabrachial nucleus.Nature metabolism · 2026Article
- Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders.Stem cell reports · 2026Article
- Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging.Cell genomics · 2026Review
- Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells.Cell stem cell · 2026Article
- Cell-type-specific architecture of the hypothalamus in a socially plastic vertebrate.bioRxiv : the preprint server for biology · 2026Article
- Hypothalamic regulation of energy homeostasis: Quo vadis.Reviews in endocrine & metabolic disorders · 2026Review
- Hypothalamic control of puberty: from neuronal circuits to mechanisms for its metabolic regulation.Reviews in endocrine & metabolic disorders · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
17 authors.
John A Tadross *Medical Research Council Metabolic Diseases Unit, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.ORCID 0000-0002-8424-1252
Lukas Steuernagel *Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.ORCID 0000-0003-0043-1436
Georgina K C Dowsett *Medical Research Council Metabolic Diseases Unit, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.
Katherine A KentistouMedical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0002-5816-664X
Sofia LundhResearch & Early Development, Novo Nordisk A/S, Måløv, Denmark.ORCID 0000-0002-4552-0312
Marta PornieceDepartment of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.ORCID 0000-0003-2330-5846
Paul KlemmDepartment of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.ORCID 0000-0002-5985-1737
Kara RainbowMedical Research Council Metabolic Diseases Unit, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.
Henning HvidResearch & Early Development, Novo Nordisk A/S, Måløv, Denmark.
Katarzyna KaniaGenomics Core, Cancer Research UK Cambridge Institute, Cambridge, UK.
Joseph Polex-WolfResearch & Early Development, Novo Nordisk A/S, Måløv, Denmark.ORCID 0000-0002-0441-8872
Lotte Bjerre KnudsenResearch & Early Development, Novo Nordisk A/S, Måløv, Denmark.ORCID 0000-0002-2439-7116
Charles PykeResearch & Early Development, Novo Nordisk A/S, Måløv, Denmark.
John R B PerryMedical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0001-6483-3771
Brian Y H LamMedical Research Council Metabolic Diseases Unit, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.ORCID 0000-0002-3638-9025
Jens C Brüning *Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany. bruening@sf.mpg.de.ORCID 0000-0002-6619-0092
Giles S H Yeo *Medical Research Council Metabolic Diseases Unit, Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK. gshy2@cam.ac.uk.ORCID 0000-0001-8823-3615
Funding
UK Medical Research CouncilWellcome Trust
Abstract
The hypothalamus is a brain region that plays a key role in coordinating fundamental biological functions
Indexed as
HypothalamusTranscriptomeAnimalsBody Mass IndexFemaleGenome-Wide Association StudyHumansMaleMiceNeuronsObesityPro-OpiomelanocortinReceptors, G-Protein-CoupledSingle-Cell AnalysisPro-OpiomelanocortinReceptors, G-Protein-Coupled
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.