ArticleNature2025
IL-27 elicits a cytotoxic CD8
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Article
- IL-27 shapes NK cell heterogeneity and function in colorectal cancer.Journal for immunotherapy of cancer · 2026Article
- Targeting the neuropilin 1/interferon γ axis restores glucocorticoid-suppressed T cell function and rescues bone formation to prevent steroid-induced osteonecrosis.Bone & joint research · 2026Article
- Local and circulating cytotoxic CD4medRxiv : the preprint server for health sciences · 2026Article
- Toll-like Receptor 3 as a Context-Dependent Molecular Switch in Epithelial Cancers: Balancing Cell Death and Tumor-Supportive Programs.International journal of molecular sciences · 2026Review
- m6A-modified circFOXA1 promotes tumor immune evasion via enhancing PD-L1 deubiquitination in triple-negative breast cancer.Cytotechnology · 2026Article
- Transforming the cytokine literature into a resource for experimental analysis and discovery.bioRxiv : the preprint server for biology · 2026Article
- Interleukin-27 remodels the bone marrow niche to suppress B-cell development and leukaemia progression in mouse models.EBioMedicine · 2026Article
- Limited protection against early-life lung murine cytomegalovirus infection results from deficiency of cytotoxic CD8 T cells.PLoS pathogens · 2026Article
- Reframing IL-27: a central regulator of CD8Trends in immunology · 2026Review
- Spatial immune hubs defined by conserved activated dendritic cells are remodeled by immunotherapy.bioRxiv : the preprint server for biology · 2026Article
- Novel Syngeneic Cell Lines for Studying High-Risk BRAFV600E-Driven Colorectal Cancer In Vivo.Cancer research communications · 2026Article
- Regulators of CD8Nature reviews. Immunology · 2026Review
- IL-27, a metabolic regulator secreted by astrocytes in response to GLP-1RA OHP2, modulates microglial reprogramming in Alzheimer's disease by regulating cGAS lactylation.Journal of neuroinflammation · 2026Article
- Impact of interaction between interleukin-27 gene polymorphisms and smoking with susceptibility to non-small cell lung cancer in Chinese Han population.World journal of surgical oncology · 2026Article
- Post-translational modifications in CD8Frontiers in immunology · 2026Review
- T-cell lymphoma-associated STAT3 variants impose a type 1 regulatory-like phenotype.Frontiers in immunology · 2026Article
- Statins attenuate PD-L1 sorting to small extracellular vesicles dependent on ubiquitin-like 3 modification.Scientific reports · 2025Article
- Mitochondria-targeted MXene@MnOBioactive materials · 2025Article
- Precision Targeting of Myeloid Cells via Peptide Dendrimer-Lipid Nanocarriers: A Novel Platform for Potent Cancer Immunotherapies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors.
Béatrice Bréart *Genentech, South San Francisco, CA, USA.
Katherine Williams *Genentech, South San Francisco, CA, USA.ORCID 0000-0001-8061-0105
Stellanie Krimm *Genentech, South San Francisco, CA, USA.
Tiffany WongGenentech, South San Francisco, CA, USA.
Brandon D KayserGenentech, South San Francisco, CA, USA.
Lifen WangGenentech, South San Francisco, CA, USA.
Eric ChengGenentech, South San Francisco, CA, USA.
Mayra Cruz TleugabulovaGenentech, South San Francisco, CA, USA.
Romain BouziatGenentech, South San Francisco, CA, USA.
Tianshi LuGenentech, South San Francisco, CA, USA.
Kobe YuenGenentech, South San Francisco, CA, USA.
Natalie S FirminoGenentech, South San Francisco, CA, USA.
Daniel D BravoGenentech, South San Francisco, CA, USA.
Juliette RoelsGenentech, South San Francisco, CA, USA.
Atish BhaktaGenentech, South San Francisco, CA, USA.
Jack BeversGenentech, South San Francisco, CA, USA.ORCID 0000-0002-9131-4173
Isabelle LehouxGenentech, South San Francisco, CA, USA.
Alan GutierrezGenentech, South San Francisco, CA, USA.
Yajun ChestnutGenentech, South San Francisco, CA, USA.
Joanna E KlementowiczGenentech, South San Francisco, CA, USA.
Teresita L ArenzanaGenentech, South San Francisco, CA, USA.
Ilseyar AkhmetzyanovaGenentech, South San Francisco, CA, USA.
Elizabeth DixonGenentech, South San Francisco, CA, USA.
Min ChenGenentech, South San Francisco, CA, USA.
Kazi TasneemGenentech, South San Francisco, CA, USA.
Rajbharan YadavGenentech, South San Francisco, CA, USA.
Hartmut KoeppenGenentech, South San Francisco, CA, USA.ORCID 0000-0003-0923-3110
Soyoung A OhGenentech, South San Francisco, CA, USA.
Lélia DelamarreGenentech, South San Francisco, CA, USA.
Haochu HuangGenentech, South San Francisco, CA, USA.
Shion A LimGenentech, South San Francisco, CA, USA.
Gerald NakamuraGenentech, South San Francisco, CA, USA.
Jianyong WangGenentech, South San Francisco, CA, USA.
Chan GaoGenentech, South San Francisco, CA, USA.
Racquel CorpuzGenentech, South San Francisco, CA, USA.
Sören MüllerGenentech, South San Francisco, CA, USA. muller.soren@gene.com.ORCID 0000-0001-9490-5270
Nathaniel R WestGenentech, South San Francisco, CA, USA. west.nathaniel@gene.com.ORCID 0000-0001-9991-0503
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although cytotoxic CD8
Indexed as
CD8-Positive T-LymphocytesInterleukin-27InterleukinsNeoplasmsT-Lymphocytes, CytotoxicAnimalsB7-H1 AntigenCell Line, TumorFemaleHumansImmunotherapyMaleMiceMice, Inbred C57BLReceptors, InterleukinTumor MicroenvironmentB7-H1 AntigenIl27 protein, mouseInterleukin-27InterleukinsMYDGF protein, humanReceptors, Interleukin
Identifiers
PMID
39910298What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.