Evidence map›Paper›PMID 39910297›Full record

ArticleNature2025

Multi-interface licensing of protein import into a phage nucleus.

Claire Kokontis, Timothy A Klein, Sukrit Silas, Joseph Bondy-Denomy

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The biology of jumbo phages.Nature communications · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Bacteriophage genome-wide transposon mutagenesis.bioRxiv : the preprint server for biology · 2025
    Article
  12. Review
  13. Article
  14. A prevalent huge phage clade in human and animal gut microbiomes.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Claire KokontisDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Timothy A KleinDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Sukrit SilasDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-3251-8579
Joseph Bondy-DenomyDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA. Joseph.Bondy-Denomy@ucsf.edu.ORCID 0000-0002-4909-9481

Funding

Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5M
Genetic and Proteomic Approaches to Reveal Bacterial Vulnerabilities to Phage PredationR01AI167412 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph Bondy-Denomy · 2022 to 2026
$3.5M
Investigating the mechanisms that make jumbophages impervious to bacterial immune systemsR01AI171041 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph Bondy-Denomy · 2022 to 2026
$2.1M
NIAID NIH HHS R01 AI167412NIAID NIH HHS R01 AI171041NIAID NIH HHS T32 AI060537
6 · The paper itself

Abstract

Bacteriophages use diverse mechanisms to evade antiphage defence systems. ΦKZ-like jumbo phages assemble a proteinaceous, nucleus-like compartment that excludes antagonistic host nucleases and also internalizes DNA replication and transcription machinery

Indexed as

BacteriophagesCell NucleusViral ProteinsActive Transport, Cell NucleusProtein TransportViral Proteins

Identifiers

PMID39910297
PMCPMC12165441

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.