ArticleScientific reports2025
An unconstrained four pool model analysis of proton relaxation and magnetization transfer in ex vivo white matter.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- SNR-Efficient Inhomogeneous Magnetization Transfer (ihMT) for Clinical Applications at 7 T.Magnetic resonance in medicine · 2026Article
- Quantitative Comparison of Multi-Echo Spin Echo and Multi-Echo Gradient Echo Myelin Water Imaging in a Panel of Mbp Enhancer-Edited Mouse Lines.Magnetic resonance in medicine · 2026Article
- MC BTS: Simultaneously Resolving Magnetization Transfer Effect and Relaxation for Multiple Components.Magnetic resonance in medicine · 2026Article
- Mapping heterogeneous region- and tissue-specific brain ageing patterns using quantitative MRI.Brain communications · 2026Article
- Evaluating the accuracy of the variable flip angle technique for temperature measurement near metallic implants.Quantitative imaging in medicine and surgery · 2025Article
- Quantum magnetization exchange through transient hydrogen bond matrix defines magnetic resonance signal relaxation and anisotropy in central nervous system.Scientific reports · 2025Article
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6 authors.
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Abstract
Understanding proton relaxation in the brain's white matter remains an active field of magnetic resonance imaging research. Models of varying complexity have been proposed to link measurements to tissue composition/microstructure, in particular myelination. Although the presence of multiple aqueous and nonaqueous proton pools is well established experimentally, so-called "quantitative MRI" is usually based on simpler models due to the large number of model parameters. In this work, a comprehensive set of parameters characterizing a four-pool model is obtained. A piece of fixed porcine spinal-cord WM was investigated at 3 T and temperatures between 21 and 35 °C. Measurements included a wide range of preparations of the spin system in combination with long echo trains to achieve sensitivity to all model parameters. The results allow the extraction of all intrinsic relaxation and exchange rates as well as assigning them to specific dynamic processes involving tissue water. A critical assessment indicates that simpler models often lack specificity to myelin.
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