Evidence map›Paper›PMID 39910119›Full record

ArticleScientific reports2025

Correlation of clinically significant prostate cancer sites across multiparametric MRI, prostate biopsy, and whole-mount pathology for optimal prostate biopsy strategy.

Matteo Pacini, Alessandro Zucchi, Riccardo Morganti, Filippo Dazzi, Antonio Luigi Pastore, Fabio Maria Valenzi, Andrea Fuschi, Yazan Al Salhi, Gianluca Giannarini, Vincenzo Ficarra and 4 more

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Matteo PaciniDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Alessandro ZucchiDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Riccardo MorgantiAzienda Ospedaliero Universitaria Pisana, UO statistica, Pisa, Italy.
Filippo DazziDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Antonio Luigi PastoreDepartment of Medical and Surgical Science and Biotechnology, La Sapienza University, Rome, Italy. antonioluigi.pastore@uniroma1.it.
Fabio Maria ValenziDepartment of Medical and Surgical Science and Biotechnology, La Sapienza University, Rome, Italy.
Andrea FuschiDepartment of Medical and Surgical Science and Biotechnology, La Sapienza University, Rome, Italy.
Yazan Al SalhiDepartment of Medical and Surgical Science and Biotechnology, La Sapienza University, Rome, Italy.
Gianluca GiannariniUrology Unit, Santa Maria della Misericordia University Hospital, Udine, Italy.
Vincenzo FicarraDepartment of Clinical and Experimental Medicinel, University of Messina, Messina, Italy.
Alchiede SimonatoDepartment of Precision Medicine in Medical, Surgical and Critical Area, University of Palermo, Palermo, Italy.
Petar AntonovDepartment of Urology and General Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria.
Pinuccia FavianaDepartment of Department of Surgery, Medical, Molecular, and Critical Area, University of Pisa, Pisa, Italy.
Riccardo BartolettiDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data from patients with suspicious lesions on multiparametric magnetic resonance (mpMRI) and a diagnosis of clinically significant prostate cancer (csPCa) who underwent radical prostatectomy (RP) were collected. The aim was to compare csPCa sites identified through whole-mount pathological analysis (WMA) after RP with PI-RADS ≥ 3 lesions identified on mpMRI, and with csPCa foci detected through targeted-biopsy (TB) or combined targeted + systematic biopsy (TSB). A paired Student's t-test and Pearson correlation analysis were performed to evaluate the agreement between these diagnostic methods. A total of 106 patients were included in the TSB group and 95 in the TB group. The correlation between mpMRI, PB, and WMA was moderate and comparable in both groups. No correlation between PB and WMA was found in the TB group for PI-RADS3 lesions, while a moderate-strong correlation was observed when comparing mpMRI, PB, and WMA for PI-RADS > 3 lesions. About 50% of csPCa sites remained undetected by mpMRI. TSB was able to identify 16.5% more csPCa sites than TB. mpMRI is an accurate method in the diagnosis of PCa, especially for PI-RADS > 3 lesions, although some csPCa sites remained undetected. The use of TSB improved the location agreement between PB and WMA, increasing detection rates up to 79%.

Indexed as

Multiparametric Magnetic Resonance ImagingProstateProstatic NeoplasmsAgedBiopsyHumansImage-Guided BiopsyMaleMiddle AgedProstatectomyMultiparametric magnetic resonanceProstate cancer diagnosisSystematic prostate biopsyTargeted fusion prostate biopsyWhole mount pathological analysis

Identifiers

PMID39910119
PMCPMC11799368

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.