Evidence map›Paper›PMID 39910106›Full record

ArticleNPJ systems biology and applications2025

Leveraging public AI tools to explore systems biology resources in mathematical modeling.

Meera Kannan, Gabrielle Bridgewater, Ming Zhang, Michael L Blinov

Abstract read
In one paragraph

Article in NPJ systems biology and applications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. The future of mathematical oncology in the age of AI.NPJ systems biology and applications · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Meera Kannan *Center for Cell Analysis and Modeling, UConn Health, Farmington, CT, 06030, USA.
Gabrielle Bridgewater *Center for Cell Analysis and Modeling, UConn Health, Farmington, CT, 06030, USA.
Ming ZhangTheoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, 87544, USA.
Michael L BlinovCenter for Cell Analysis and Modeling, UConn Health, Farmington, CT, 06030, USA. blinov@uchc.edu.

Funding

TR&D3: Standards and Tools for Simulator Composition and Credibility portalP41EB023912 · NIBIB · UNIVERSITY OF WASHINGTON · PI HERBERT M. SAURO · 2018 to 2026
$11.4M
Mechanistic Modeling of Cellular SystemsR24GM137787 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Pedro Mendes, Ion I. Moraru · 2020 to 2026
$8.9M
A novel approach to pinpoint predisposed recombination regions in HIV for a global profile of HIV recombinants' occurrence and evolutionR21AI176947 · NIAID · UNIVERSITY OF GEORGIA · PI HUANG, HANWEN, SONG, XIAO · 2023 to 2024
$386k
NIAID NIH HHS R21 AI176947NIBIB NIH HHS P41 EB023912NIGMS NIH HHS R24 GM137787
6 · The paper itself

Abstract

Predictive mathematical modeling is an essential part of systems biology and is interconnected with information management. Systems biology information is often stored in specialized formats to facilitate data storage and analysis. These formats are not designed for easy human readability and thus require specialized software to visualize and interpret results. Therefore, comprehending modeling and underlying networks and pathways is contingent on mastering systems biology tools, which is particularly challenging for users with no or little background in data science or system biology. To address this challenge, we investigated the usage of public Artificial Intelligence (AI) tools in exploring systems biology resources in mathematical modeling. We tested public AI's understanding of mathematics in models, related systems biology data, and the complexity of model structures. Our approach can enhance the accessibility of systems biology for non-system biologists and help them understand systems biology without a deep learning curve.

Indexed as

Artificial IntelligenceModels, TheoreticalSystems BiologyHumansModels, BiologicalSoftware

Identifiers

PMID39910106
PMCPMC11799200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.