Evidence map›Paper›PMID 39910076›Full record

ArticleNature communications2025

Distributed cross-learning for equitable federated models - privacy-preserving prediction on data from five California hospitals.

Tsung-Ting Kuo, Rodney A Gabriel, Jejo Koola, Robert T Schooley, Lucila Ohno-Machado

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tsung-Ting KuoDepartment of Biomedical Informatics and Data Science, School of Medicine, Yale University, New Haven, Connecticut, United States of America. tsung-ting.kuo@yale.edu.ORCID http://orcid.org/0000-0002-8728-4477
Rodney A GabrielDivision of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, California, United States of America.
Jejo KoolaDivision of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, California, United States of America.
Robert T SchooleyDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California, United States of America.ORCID http://orcid.org/0000-0002-2498-8426
Lucila Ohno-MachadoDepartment of Biomedical Informatics and Data Science, School of Medicine, Yale University, New Haven, Connecticut, United States of America.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Genetic & Social Determinants of Health: Center for Admixture Science and TechnologyRM1HG011558 · NHGRI · YALE UNIVERSITY · PI FRAZER, KELLY A, GYMREK, MELISSA · 2021 to 2025
$11.2M
Ethics Core (FABRIC)U54HG012510 · NHGRI · YALE UNIVERSITY · PI MALIN, BRADLEY A. · 2022 to 2025
$11.2M
San Diego Biomedical Informatics Education & Research (SABER)T15LM011271 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAMIM NEMATI · 2012 to 2026
$9.7M
Protecting Privacy and Facilitating Shared Access of Clinical and Genetic Data of Special PopulationsR01HL136835 · NHLBI · YALE UNIVERSITY · PI OHNO-MACHADO, LUCILA · 2018 to 2022
$6.5M
iAGREE: A Multi-Center, Networked Patient Consent StudyR01HG011066 · NHGRI · YALE UNIVERSITY · PI OHNO-MACHADO, LUCILA · 2020 to 2024
$4.2M
Decentralized differentially-private methods for dynamic data release and analysisR01LM013712 · NLM · YALE UNIVERSITY · PI JIANG, XIAOQIAN, OHNO-MACHADO, LUCILA · 2022 to 2025
$2.5M
SOCAL: Privacy-protecting Sharing Of Clinical Data Across LaboratoriesR01EB031030 · NIBIB · YALE UNIVERSITY · PI KUO, TSUNG-TING · 2022 to 2025
$1.3M
NCATS NIH HHS UL1 TR001863NHGRI NIH HHS R01 HG011066NHGRI NIH HHS RM1 HG011558NHGRI NIH HHS U54 HG012510NHLBI NIH HHS R01 HL136835NIBIB NIH HHS R01 EB031030NLM NIH HHS R01 LM013712NLM NIH HHS T15 LM011271U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01EB031030U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HG011066U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL136835U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01LM013712U.S. Department of Health & Human Services | National Institutes of Health (NIH) RM1HG011558U.S. Department of Health & Human Services | National Institutes of Health (NIH) U54HG012510
6 · The paper itself

Abstract

Quality improvement, clinical research, and patient care can be supported by medical predictive analytics. Predictive models can be improved by integrating more patient records from different healthcare centers (horizontal) or integrating parts of information of a patient from different centers (vertical). We introduce Distributed Cross-Learning for Equitable Federated models (D-CLEF), which incorporates horizontally- or vertically-partitioned data without disseminating patient-level records, to protect patients' privacy. We compared D-CLEF with centralized/siloed/federated learning in horizontal or vertical scenarios. Using data of more than 15,000 patients with COVID-19 from five University of California (UC) Health medical centers, surgical data from UC San Diego, and heart disease data from Edinburgh, UK, D-CLEF performed close to the centralized solution, outperforming the siloed ones, and equivalent to the federated learning counterparts, but with increased synchronization time. Here, we show that D-CLEF presents a promising accelerator for healthcare systems to collaborate without submitting their patient data outside their own systems.

Indexed as

ConfidentialityHospitalsPrivacyCaliforniaCOVID-19Electronic Health RecordsHumansSARS-CoV-2

Identifiers

PMID39910076
PMCPMC11799213

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.