Evidence map›Paper›PMID 39910040›Full record

ArticleTranslational psychiatry2025

Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome project.

Hai Le, Daphna Fenchel, Konstantina Dimitrakopoulou, Hamel Patel, Charles Curtis, Lucilio Cordero-Grande, A David Edwards, Joseph Hajnal, Jacques-Donald Tournier, Maria Deprez and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hai LeResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. L.haibg@gmail.com.ORCID http://orcid.org/0000-0001-6221-6980
Daphna FenchelResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Konstantina DimitrakopoulouTranslational Bioinformatics Platform, NIHR Biomedical Research Centre, Guy's and St. Thomas' NHS Foundation Trust and King's College London, London, UK.
Hamel PatelNIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust & Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-7951-6728
Charles CurtisNIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust & Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Lucilio Cordero-GrandeResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0003-1477-304X
A David EdwardsResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0003-4801-7066
Joseph HajnalResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0002-2690-5495
Jacques-Donald TournierResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Maria DeprezResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Harriet CullenResearch Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0002-2846-1621

Funding

Comunidad de Madrid BGP18/00178RCUK | Medical Research Council (MRC) MR/N013700/1Wellcome Trust
6 · The paper itself

Abstract

Increasing lines of evidence suggest cerebral overgrowth in autism spectrum disorder (ASD) children in early life, but few studies have examined the effect of ASD common genetic variants on brain volumes in a general paediatric population. This study examined the association between ASD polygenic risk score (PRS) and volumes of the frontal, temporal, parietal, occipital, fronto-temporal and parieto-occipital lobes in 273 term-born infants of European ancestry in the developing Human Connectome Project. ASD PRS was positively associated with frontal (β = 0.027, p

Indexed as

Autism Spectrum DisorderConnectomeCross-Sectional StudiesFemaleHumansInfant, NewbornMagnetic Resonance ImagingMaleMultifactorial InheritanceOrgan SizeWhite People

Identifiers

PMID39910040
PMCPMC11799222

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.