Evidence map›Paper›PMID 39910030›Full record

ArticleNature communications2025

Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry.

Makusu Tsutsui, Wei-Lun Hsu, Chien Hsu, Denis Garoli, Shukun Weng, Hirofumi Daiguji, Tomoji Kawai

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Makusu TsutsuiThe Institute of Scientific and Industrial Research, Osaka University, Mihogaoka 8-1, Ibaraki, Osaka, 567-0047, Japan. tsutsui@sanken.osaka-u.ac.jp.ORCID http://orcid.org/0000-0002-4552-1163
Wei-Lun HsuDepartment of Mechanical Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.ORCID http://orcid.org/0000-0002-5451-4301
Chien HsuDepartment of Mechanical Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.ORCID http://orcid.org/0000-0003-2663-539X
Denis GaroliIstituto Italiano di Tecnologia, Optoelectronics Research Line, Morego 30, I-16163, Genova, Italy.ORCID http://orcid.org/0000-0002-5418-7494
Shukun WengDipartimento di scienze e metodi dell'ingegneria, Università degli studi di modena e reggio emilia, 42122, Reggio emilia, Italy.
Hirofumi DaigujiDepartment of Mechanical Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.ORCID http://orcid.org/0000-0001-6896-3282
Tomoji KawaiThe Institute of Scientific and Industrial Research, Osaka University, Mihogaoka 8-1, Ibaraki, Osaka, 567-0047, Japan. kawai@sanken.osaka-u.ac.jp.

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 22H01926MEXT | Japan Society for the Promotion of Science (JSPS) 24K21715
6 · The paper itself

Abstract

Gating is a fundamental process in ion channels configured to open and close in response to specific stimuli such as voltage across cell membranes thereby enabling the excitability of neurons. Here we report on voltage-gated solid-state nanopores by electrically tunable chemical reactions. We demonstrate repetitive precipitation and dissolution of metal phosphates in a pore through manipulations of cation flow by transmembrane voltage. Under negative voltages, precipitates grow to reduce ionic current by occluding the nanopore, while inverting the voltage polarity dissolves the phosphate compounds reopening the pore to ionic flux. Reversible actuation of these physicochemical processes creates a nanofluidic diode of rectification ratio exceeding 40000. The dynamic nature of the in-pore reactions also facilitates a memristor of sub-nanowatt power consumption. Leveraging chemical degrees of freedom, the present method may be useful for creating iontronic circuits of tunable characteristics toward neuromorphic systems.

Identifiers

PMID39910030
PMCPMC11799347

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.