ArticleBritish journal of anaesthesia2025
Impact of age on the reliability of GE Entropy™ module indices for guidance of maintenance of anaesthesia in adult patients: a single-centre retrospective analysis.
Article in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Comparative analysis of processed EEG indices and entropy-based metrics for assessing anesthetic depth: a scoping review - PRISMA-ScR.BMC biomedical engineering · 2026Article
- Target controlled infusion in the intensive care unit: a scoping review.Journal of clinical monitoring and computing · 2026Article
- Evaluating the performance of the NarcotrendBMC anesthesiology · 2025Article
- Impact of ageing on sevoflurane's hypnotic potency and induction kinetics during wash-in period: A prospective observational study.Indian journal of anaesthesia · 2025Article
- Age-specific electroencephalography dynamics during anesthesia: monitoring and neurocognitive implications.Anesthesia and pain medicine · 2025Review
- Does titration of anaesthesia using population-derived EEG indices overdose older patients?British journal of anaesthesia · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe GE Entropy™ module uses frontal EEG to compute the processed indices state entropy (SE), response entropy (RE), and burst suppression ratio (BSR) to guide maintenance of anaesthesia by supposedly minimising overly 'deep' or 'light' anaesthesia. It remains unclear whether the manufacturer-recommended index ranges accurately reflect anaesthesia levels or prevent complications such as burst suppression or arousal reactions.
methodsWe retrospectively analysed 15 608 patient records, evaluating 14 770 adult patients (18-90 yr old) undergoing general anaesthesia. Age-dependent effects on processed index values were assessed using linear regression and Spearman's correlation coefficients (rho).
resultsDuring steady-state anaesthesia (BSR=0), only 38.4% (32.5-42.4%) of SE values were within the recommended range, with most values below the target. Age was positively associated with an increase in age-adjusted minimal alveolar concentration for volatile anaesthetics (adjusted [adj.] R
conclusionsDespite their intuitive appeal, the processed EEG index values SE, RE, ΔRE-SE, and BSR showed limited reliability in guiding maintenance of anaesthesia, especially in older patients. Anaesthesiologists should not rely exclusively on the recommended index value range, as it is often unattainable and does not prevent burst suppression or arousal indicators.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.