Evidence map›Paper›PMID 39909708›Full record

ArticleThe American journal of clinical nutrition2025

Relationship between gestational weight gain with fetal body composition and organ volumes in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Dimensional Study: a prospective pregnancy cohort.

Kathryn A Wagner, Zhen Chen, Stefanie N Hinkle, Jessica L Gleason, Wesley Lee, William A Grobman, John Owen, Roger B Newman, Daniel W Skupski, Dian He and 5 more

2 registry-linked trialsAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00912132 completednot on this map

The National Standard for Normal Fetal Growth

TypeobservationalSponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Ran2009 to 2013Enrolled2,802ConditionsPregnancy, Fetal Growth
NCT03266198 completednot on this map

Fetal Body Composition and Volumes Study

TypeobservationalSponsorKatherine GrantzRan2016 to 2019Enrolled2,809ConditionsFetal Growth Restriction, Fetal Growth AbnormalityArmsNo intervention
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kathryn A WagnerEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Zhen ChenBiostatistics and Bioinformatics Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Stefanie N HinkleDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, United States.
Jessica L GleasonEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Wesley LeeDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, United States.
William A GrobmanThe Ohio State University Wexner Medical Center Department of Obstetrics and Gynecology, Columbus, OH, United States.
John OwenDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, United States.
Roger B NewmanDepartment of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC, United States.
Daniel W SkupskiWeill Cornell Medicine - New York Presbyterian Queens, Flushing, NY, United States.
Dian HeEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States; The Prospective Group, Inc., Fairfax, VA, United States.
Seth ShermanThe Emmes Company, Rockville, MD, United States.
Robert E Gore-LangtonThe Emmes Company, Rockville, MD, United States.
Cuilin ZhangEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States; Global Center for Asian Women's Health (Glow) and Bia-Echo Asia Centre for Reproductive Longevity & Equality (ACRLE), Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Jagteshwar GrewalDivision of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.
Katherine L GrantzEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States. Electronic address: katherine.grantz@nih.gov.

Funding

NICHD NIH HHS HHSN275200800012CNICHD NIH HHS HHSN275200800013CNICHD NIH HHS HHSN275200800014CNICHD NIH HHS HHSN275200800028CNICHD NIH HHS HHSN275201000008CNICHD NIH HHS HHSN275201300025INICHD NIH HHS HHSN275201500002C
6 · The paper itself

Abstract

backgroundInadequate and excessive gestational weight gain (GWG) are associated with increased risk of newborn small- and large-for-gestational-age, respectively, and future offspring adiposity. However, the relationship between GWG and three-dimensional (3D) measures of fetal body composition and organ volumes, which may provide greater insight into fetal growth via measurement of soft tissue, remains unknown.

objectivesThe objective of this study was to examine the relationship between trimester-specific GWG and 3D fetal body composition and organ volume measurements.

methodsIn a diverse, US prospective pregnancy cohort, trimester-specific GWG was calculated as difference between maternal weight at beginning and end of each trimester, and categorized as inadequate, adequate, or excessive, per 2009 Institute of Medicine (IOM) guidelines. Up to five 3D ultrasound scans were completed across gestation, from which fetal body composition and organ volume measurements were obtained (n = 2675 pregnancies). The associations between trimester-specific GWG categories and 3D fetal body composition and organ volumes were assessed at 15, 29, and 39 weeks.

resultsExcessive compared with adequate GWG, in first and second trimesters was associated with larger abdominal circumference (n = 2430; 1st trimester: 1.29 cm, 95% CI: 0.74, 1.84; 2nd trimester: 2.98 cm, 95% CI: 1.62, 4.34) and abdominal area (n = 2401; 1st trimester: 22.04 mm

conclusionsExcessive GWG was associated with greater fetal size primarily manifested by a pattern of fat accumulation across the fetal arm and abdomen. Future studies should examine whether these fetal changes have functional implications for childhood adiposity and metabolic dysfunction. This trial was registered at https://clinicaltrials.gov as NCT00912132 and NCT03266198.

Indexed as

Body CompositionFetal DevelopmentFetusGestational Weight GainAdultCohort StudiesFemaleHumansInfant, NewbornNational Institute of Child Health and Human Development (U.S.)Organ SizePregnancyProspective StudiesUltrasonography, PrenatalUnited StatesYoung Adultfetal body compositionfetal growthfetal volumegestational weight gainPregnancythree-dimensional ultrasound

Identifiers

PMID39909708
PMCPMC11863319

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.