Evidence map›Paper›PMID 39909575›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

A New Insight into the Role of CART Peptide in Serotonergic Function and Anxiety.

Nagalakshmi Balasubramanian, Ruixiang Wang, Shafa Ismail, Benjamin Hartman, Zeid Aboushaar, Catherine A Marcinkiewcz

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Dorsal raphe tau pathology disrupts sleep-wake orchestration and sleep architecture in a sex-specific manner.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nagalakshmi BalasubramanianDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa 52242.ORCID 0000-0001-6278-0231
Ruixiang WangDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa 52242.
Shafa IsmailDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa 52242.
Benjamin HartmanDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa 52242.
Zeid AboushaarDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa 52242.
Catherine A MarcinkiewczDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa 52242 catherine-marcinkiewcz@uiowa.edu.

Funding

University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)P50HD103556 · NICHD · UNIVERSITY OF IOWA · PI EDWIN TED G. ABEL, Lane Strathearn · 2021 to 2026
$8.5M
NICHD NIH HHS P50 HD103556
6 · The paper itself

Abstract

Cocaine- and amphetamine-regulated transcript (CART) peptide has been implicated in stress-related behaviors that are regulated by central serotonergic (5-HT) systems in the dorsal raphe nucleus (DRN). Here, we aimed to investigate the interaction between CART and DRN 5-HTergic systems after initially observing CART axonal terminals in the DRN. We found that microinfusion of CART peptide

Indexed as

AnxietyDorsal Raphe NucleusNerve Tissue ProteinsSerotonergic NeuronsSerotoninAnimalsCocaine- and Amphetamine-Regulated Transcript ProteinFemaleMaleMiceMice, Inbred C57BLCocaine- and Amphetamine-Regulated Transcript ProteinNerve Tissue ProteinsSerotonin5-HTanxietyCARTdorsal raphe nucleusEdinger–Westphal nucleus

Identifiers

PMID39909575
PMCPMC11800755

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.