ReviewRegional anesthesia and pain medicine2025
Chronic postsurgical pain and transitional pain services: a narrative review highlighting European perspectives.
Review in Regional anesthesia and pain medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sensory Abnormalities and Pain in the Donor Sites of Radial Forearm and Fibula Free Flaps-A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Liposomal bupivacaine versus ropivacaine for surgical site infiltration in lumbar fusion: a prospective randomized controlled trial.Annals of medicine · 2026Trial
- Early repetitive transcranial magnetic stimulation for preventing chronic postoperative pain in older adults: a randomized clinical sub-study.BMC medicine · 2026Trial
- The Evolving Role of Peripheral Nerve Stimulation in Postoperative Analgesia and Recovery.Current pain and headache reports · 2026Review
- Personalized Prediction of Acute and Chronic Postsurgical Pain - the role of Multidomain Biosignatures, Machine Learning-Based Integration, and Standardized Outcome Definitions.Current pain and headache reports · 2026Review
- A 5-Item Prediction Model Incorporating Pain With Neuropathic Characteristics at 2 Weeks for Chronic Postsurgical Pain After Video-Assisted Thoracoscopic Lung Surgery: A Prospective Cohort Study.European journal of pain (London, England) · 2026Article
- Impact of multimodal analgesia using intravenous non-opioid agents on immediate postoperative rescue analgesic use following minor general surgery: a retrospective study.The Korean journal of pain · 2026Article
- Healing from the Inside Out: Vitamins and Nutritional Strategies for Complex Regional Pain Syndrome and Chronic Postsurgical Pain.Current pain and headache reports · 2026Review
- The Role of Dexketoprofen/Tramadol in Multimodal Therapy to Prevent Acute Postsurgical and Acute Low Back Pain from Developing into Chronic Pain: A Delphi Consensus Study.Pain and therapy · 2026Article
- Development of a clinical prediction model for chronic post-surgical shoulder pain following arthroscopic rotator cuff repair: A prospective cohort study.Shoulder & elbow · 2026Article
- Healthcare professionals' perspectives on the utility of chronic postsurgical pain prediction profiles in perioperative care: a qualitative study.Journal of anesthesia, analgesia and critical care · 2026Article
- Pain Persisting After Bone Marrow Aspiration and Biopsy: Clinical Features, Pain Phenotypes, and Prospective Outcomes.Journal of pain research · 2026Article
- Application of nerve blocks in breast surgery: evolution and prospects from efficacy comparison to multidimensional assessment and precision application.Frontiers in surgery · 2026Review
- Transitional Pain Services and Clinics: A Scoping Review of Recent Literature.Journal of pain research · 2026Review
- Cognitive Behavioral Therapy and Pain Chronification: Neuroimmune Rationale, Evidence Boundaries, and Trial Design Priorities: A Structured Narrative Review.Journal of pain research · 2026Review
- Parental upheaval experienced in childhood and its effect on pain-related cognitions across the lifespan: an exploratory investigation.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- "Pain Prehabilitation" in Major Joint Surgery: The Way Forward to Improve Outcomes and Prevent Pain Chronicity.Journal of clinical medicine · 2025Review
- Chronic Groin Pain After Hernia Surgery: What Are We Missing?Journal of clinical medicine · 2025Review
- Balanced Opioid-Free Anesthesia on Chronic Postsurgical Pain After Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Trial Protocol.Journal of pain research · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background/importanceChronic postsurgical pain (CPSP) is a significant, often debilitating outcome of surgery, impacting patients' quality of life and placing a substantial burden on healthcare systems worldwide. CPSP (pain persisting for more than 3 months postsurgery) leads to both physical and psychological distress. Recognized as a distinct chronic pain entity in International Classification of Diseases, 11th Revision, CPSP enables better reporting and improved management strategies. Despite advancements in surgical care, CPSP remains prevalent, affecting 5%-85% of patients, with higher rates following thoracotomies, amputations, mastectomies and joint replacements.
objectiveThe acute to chronic pain transition involves complex interactions between peripheral and central mechanisms, with central sensitization playing a key role. Identifying high-risk patients is crucial for prevention, with factors such as surgical type, nerve injury, neuropathic elements in acute postoperative pain, and psychosocial conditions being significant contributors. EVIDENCE REVIEW: Current pain management strategies, including multimodal therapy and regional anesthesia, show limited effectiveness in preventing CPSP. Neuromodulation interventions, though promising, are not yet established as preventive modalities.
findingsTransitional pain services (TPSs) offer a comprehensive, multidisciplinary approach to managing CPSP and reducing opioid dependence, addressing both physical and psychosocial aspects of functional recovery. While promising results have been seen in Canada and Finland, TPSs are not yet widely implemented in Europe. There is also growing interest in pain biomarkers, through initiatives such as the A2CPS program, aiming to improve CPSP prediction and develop targeted interventions.
conclusionsFuture research should focus on large-scale studies integrating various factors to facilitate CPSP prediction, refine prevention strategies and reduce its long-term impact.
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