ArticleLaboratory investigation; a journal of technical methods and pathology2025
Rapid, Point-of-Care Bone Marrow Aspirate Adequacy Assessment Via Deep Ultraviolet Microscopy.
Article in Laboratory investigation; a journal of technical methods and pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Nondestructive, High-Resolution T Cell Characterization and Subtyping via Deep-UV Microscopy.BME frontiers · 2026Article
- Label-free deep UV microscopy in oral cytology: a step towards stain-free diagnostics.Biomedical optics express · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
Bone marrow aspirations are pivotal for diagnosing and monitoring various hematological conditions, including cancers. However, a significant portion (10%-50%) of aspirations yield suboptimal or inadequate diagnostic material. The difficulty and scarcity of bedside adequacy assessment strategies further exacerbate the challenges in this procedure, which can consequently lead to delays in diagnosis and treatment, among other complications. To address this unmet clinical need, we apply deep UV microscopy, a real-time, low-cost, label-free molecular imaging technology that recapitulates the appearance of Giemsa stains. We present results from a prospective clinical study comprising 51 pediatric oncology patients, where the deep UV images of unstained bone marrow aspirate smears are evaluated and compared with the clinical standard of care (a hematopathologist inspection of the same slides after Giemsa staining). Results show that both real-time visual UV inspection and an automated classification algorithm applied to the unstained deep UV images achieve accurate adequacy assessment, with accuracies of 94.1% and 95.7%, respectively. Additionally, we demonstrate whole-slide imaging of bone marrow aspirate smears using a compact and low-cost deep UV microscope that is well suited for point-of-care use. Together, this work has significant implications for improving bone marrow aspirations and the clinical management of many hematological patients.
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