Evidence map›Paper›PMID 39908544›Full record

ArticleJMIR research protocols2025

Effect of Medication Management at Home via Pharmacist-Led Home Televisits: Protocol for a Cluster Randomized Controlled Trial.

Sheikh Rubana Hossain, Akanksha N Samant, Briana C Balsamo, Chelsea E Hawley, Michael C Zanchelli, Carolyn Zhu, Maria D Venegas, Marina Robertson, Megan B McCullough, Judith L Beizer and 4 more

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in JMIR research protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04340570 (Effect of Medication Management at Home Via Pharmacy Home Televisits), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04340570 nacompletednot on this map

Effect of Medication Management at Home Via Pharmacy Home Televisits

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2020 to 2025Enrolled304ConditionsPolypharmacy, Deprescribing, TelemedicineArmsMedication management via televisit to home
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sheikh Rubana Hossain *James J Peters VA Medical Center, Bronx, NY, United States.ORCID 0009-0001-8084-8460
Akanksha N Samant *James J Peters VA Medical Center, Bronx, NY, United States.ORCID 0009-0008-1179-1115
Briana C BalsamoPharmacy Department, James J Peters VA Medical Center, Bronx, NY, United States.ORCID 0009-0007-0323-4012
Chelsea E HawleyNew England Geriatric Research Education and Clinical Center, Bedford, MA, United States.ORCID 0000-0002-6136-8189
Michael C ZanchelliJames J Peters VA Medical Center, Bronx, NY, United States.ORCID 0009-0004-1249-4471
Carolyn ZhuJames J Peters VA Medical Center, Bronx, NY, United States.ORCID 0000-0002-2318-715X
Maria D VenegasNew England Geriatric Research Education and Clinical Center, Bedford, MA, United States.ORCID 0000-0002-2740-2267
Marina RobertsonPharmacy Department, James J Peters VA Medical Center, Bronx, NY, United States.ORCID 0009-0006-1473-1113
Megan B McCulloughCenter for Healthcare Organization and Implementation Research, Bedford VA Medical Center, Bedford, MA, United States.ORCID 0000-0002-3387-1967
Judith L BeizerCollege of Pharmacy and Health Sciences, St John's University, New York, NY, United States.ORCID 0009-0008-1136-9336
Kenneth S BoockvarUniversity of Alabama at Birmingham, Birmingham, AL, United States.ORCID 0000-0003-1165-5558
Albert L SiuJames J Peters VA Medical Center, Bronx, NY, United States.ORCID 0000-0001-6330-8502
Lauren R MooNew England Geriatric Research Education and Clinical Center, Bedford, MA, United States.ORCID 0000-0003-2951-8674
William W HungJames J Peters VA Medical Center, Bronx, NY, United States.ORCID 0009-0004-8283-3643

Funding

Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Margaret Sewell · 2020 to 2026
$31.0M
HSRD VA I01 HX002826NIA NIH HHS P30 AG066514
6 · The paper itself

Abstract

backgroundOlder adults are more likely to have multiple chronic conditions, be prescribed multiple medications, and be more susceptible to adverse drug reactions (ADRs) to their medications. In addition, older adults often use over-the-counter medications and supplements, further complicating their medication regimens. Complex medication regimens are potentially harmful to older adults. Interventions aimed at reducing medication discrepancy in the ambulatory clinic setting, such as reviews of medication lists and the implementation of "brown bag" reconciliation, continue to be challenging, with limited success. Pharmacist-led interventions to improve appropriate medication use in older adults have demonstrated effectiveness in reducing ADRs. Video visits have the potential to provide direct visualization of medications in older adults' homes, thereby reducing medication discrepancy and increasing medication adherence. Pharmacist-led management of older adults' medication regimens may improve appropriate medication use in older adults.

objectiveThe objective of this study is to examine the effect of pharmacist-led medication through home televisits compared to usual care on appropriate medication use, medication discrepancies, medication adherence, and ADRs.

methodsWe will conduct a 2-site cluster randomized controlled trial (RCT). The intervention will be a pharmacist-led home televisit including medication reconciliation and assessment of actual medication use. The cluster RCT was iteratively adapted after a pilot test. The primary outcome of medication appropriateness of the intervention will be measured using the STOPP (Screening Tool of Older Persons' Prescriptions) criteria for potentially inappropriate medications (PIMs) at 6 months. Medication lists obtained will be compared against electronic medical records (EMRs) by a clinician to establish discrepancies in medications. The clinician will review medications using the validated Medication Appropriateness Index (MAI).

resultsThis project has been peer-reviewed and selected for support by the Veterans Affairs (VA) Health Services Research Service. The pilot phase of the study was completed December 2021 with 20 veterans and was primarily informed by the Steinman model of the prescribing process adapted to include system- and provider-level factors. The last date of enrollment was August 6, 2021. We anticipate the completion of the ongoing trial in spring 2025. The first results are expected to be submitted for publication in 2025.

conclusionsThe cluster RCT will provide evidence on medication management through televisits. If found effective in improving the use of medications, the intervention has the potential to impact older adults with multiple chronic conditions and polypharmacy.

trial registrationClinicalTrials.gov NCT04340570; https://clinicaltrials.gov/study/NCT04340570. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/65141.

Indexed as

Home Care ServicesMedication Therapy ManagementPharmacistsAgedFemaleHumansMaleMedication AdherenceMedication ReconciliationMulticenter Studies as TopicRandomized Controlled Trials as Topicadverse drug reactionmedication managementolder adultspolypharmacytelevisit

Identifiers

PMID39908544
PMCPMC11840363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.