Evidence map›Paper›PMID 39908486›Full record

ArticleOcular immunology and inflammation2025

Incidence and Outcomes of Cataract in Eyes with Ocular Cicatricial Pemphigoid.

Pichaporn Artornsombudh, Maxwell Pistilli, Craig W Newcomb, C Stephen Foster, Douglas A Jabs, Jennifer E Thorne, Nirali P Bhatt, James T Rosenbaum, Grace A Levy-Clarke, H Nida Sen and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ocular immunology and inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Pichaporn ArtornsombudhDepartment of Ophthalmology, Somdech Phra Pinklao Hospital, Royal Thai Navy, Bangkok, Thailand.
Maxwell PistilliScheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Craig W NewcombBiostatistical Analysis Center, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
C Stephen FosterDepartment of Ophthalmology, Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts, USA.ORCID 0000-0002-6612-5653
Douglas A JabsWilmer Eye Institute, Department of Ophthalmology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Jennifer E ThorneWilmer Eye Institute, Department of Ophthalmology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Nirali P BhattScheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
James T RosenbaumDepartment of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.
Grace A Levy-ClarkeDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, West Virginia, USA.
H Nida SenDepartment od Ophthalmology, George Washington University, Washington, District of Columbia, USA.
Eric B SuhlerDepartment of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.
Kurt A DregerDepartment of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Jeanine M BuchanichCenter for Occupational Biostatistics and Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA.
Hosne BegumWilmer Eye Institute, Department of Ophthalmology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Tonetta D FitzgeraldScheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Naira KhachatryanDepartment of Ophthalmology, Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts, USA.
Teresa L LiesegangDepartment of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.
Gui-Shuang YingScheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Sapna S GangaputraVanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
John H KempenDepartment of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-2967-4792
Site Cohort Study Research GroupDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Funding

Long-term Follow-up of the Systemic Immunosuppressive Therapy for Eye Diseases CohortR01EY014943 · NEI · UNIVERSITY OF PENNSYLVANIA · PI KEMPEN, JOHN H · 2004 to 2025
$8.1M
Incidence of remission and of cataract in ocular inflammatory diseasesR21EY026717 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI KEMPEN, JOHN H · 2017 to 2018
$495k
Outcomes of uveitic cataract and uveitic glaucoma surgeryR21EY032592 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GANGAPUTRA, SAPNA S · 2021 to 2022
$488k
NEI NIH HHS R01 EY014943NEI NIH HHS R21 EY026717NEI NIH HHS R21 EY032592
6 · The paper itself

Abstract

purposeTo identify the incidence of cataract and the outcomes of cataract surgery in eyes with ocular cicatricial pemphigoid (OCP).

methodsPhakic eyes were identified from the Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study and followed for the incidence of visually significant cataract defined as: newly reduced visual acuity 20/50 or worse attributed to cataract; and/or incident cataract surgery. Secondarily, all eyes with OCP that underwent cataract surgery and had a year of follow up thereafter, were included in an analysis of visual outcome.

resultsThree hundred fifty-five phakic eyes (200 patients) with OCP were at risk. Eighty eyes developed visually significant cataract over 1064 eye years (incidence rate = 7.5%/eye-year, 95% confidence interval [CI] = 5.6 to 10.1). Higher age was associated with increased incidence of cataract (adjusted hazard ratio [aHR] = 4.47; 95% CI, 1.95-10.23 for age 60-75 inclusive and aHR = 8.37; 95% CI, 3.60-19.42 for age > 75, each compared with age <60 years). Seventy-nine eyes of 61 patients were monitored for > = 1 year following cataract surgery. Cataract surgery was associated with an improvement of vision around 4 lines, which was sustained through at least 48 months. Poorer pre-operative visual acuity was associated with poorer long-term visual outcome.

conclusionsThe incidence of cataract was high in this older population. No factors predictive of cataract such as duration of OCP or use of corticosteroids were identified. Visual acuity improved after surgery by a median of 4 lines' gain at one year; poorer long-term outcome among those with initially poorer visual acuity may be secondary to corneal scarring.

Indexed as

CataractCataract ExtractionPemphigoid, Benign Mucous MembraneAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedRetrospective StudiesRisk FactorsVisual AcuityAge-related cataract surgeryincidence of cataractocular cicatricial pemphigoidoutcome of cataract surgeryvisual improvement

Identifiers

PMID39908486
PMCPMC12187555

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.