Evidence map›Paper›PMID 39908480›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2025

Fluorescein Angiography as a Surrogate Marker of Disease Activity in Susac Syndrome.

Laura Guttieres, Lea Vannelli, Sarah Demortiere, Marine Perriguey, Maya Elziere, Pierre Durozard, Clemence Boutiere, Audrey Rico, Frederic Hilezian, Jan-Patrick Stellmann and 4 more

Abstract readEvaluation Study
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Laura GuttieresDepartment of Neurology, University Hospital of Marseille, France.
Lea VannelliDepartment of Ophthalmology, University Hospital of Marseille, France.
Sarah DemortiereDepartment of Neurology, University Hospital of Marseille, France.ORCID 0000-0002-8513-5443
Marine PerrigueyDepartment of Neurology, University Hospital of Marseille, France.ORCID 0000-0002-9470-0563
Maya ElziereVertigo Center, European Hospital, Marseille, France.
Pierre DurozardCentre Hospitalier d'Ajaccio, Ajaccio, France.ORCID 0000-0003-3459-7741
Clemence BoutiereDepartment of Neurology, University Hospital of Marseille, France.ORCID 0009-0001-3119-8203
Audrey RicoDepartment of Neurology, University Hospital of Marseille, France.ORCID 0009-0002-5395-9963
Frederic HilezianVertigo Center, European Hospital, Marseille, France.ORCID 0000-0002-5854-9325
Jan-Patrick StellmannAix Marseille Univ, CNRS, CRMBM, France.ORCID 0000-0003-2565-2833
Jean PelletierDepartment of Neurology, University Hospital of Marseille, France.ORCID 0000-0001-9730-7567
Adil MaaroufDepartment of Neurology, University Hospital of Marseille, France.ORCID 0000-0002-6755-496X
Natacha StolowyDepartment of Ophthalmology, University Hospital of Marseille, France.ORCID 0000-0003-3662-3800
Bertrand AudoinDepartment of Neurology, University Hospital of Marseille, France.ORCID 0000-0002-9860-7657

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the sensitivity of fluorescein angiography (FA) in detecting disease activity in Susac syndrome.

methodsWe conducted a blinded analysis of all FA, brain MRI, and audiogram examinations performed throughout the follow-up of patients with Susac syndrome.

resultsA total of 79 FA examinations, 85 brain MRI scans, and 49 audiograms were analyzed from 9 patients followed for a mean (SD) period of 6 (4) years. Disease activity was detected in 41.5% of FA examinations, 10.5% of MRI scans, and 25% of audiograms (FA vs MRI, DISCUSSION: FA, particularly arterial leakage, demonstrated the highest sensitivity in detecting disease activity and may be a valuable tool for treatment management in Susac syndrome. Future studies with larger samples should aim to identify the optimal threshold of FA changes associated with an increased risk of relapse.

Indexed as

Fluorescein AngiographySusac SyndromeAdolescentAdultBrainFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleRetinaRetinal ArterySensitivity and SpecificityYoung Adult

Identifiers

PMID39908480
PMCPMC11805606

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.