Evidence map›Paper›PMID 39908436›Full record

ArticleThe New England journal of medicine2025

Identifying and Targeting TNF Signaling in Idiopathic Multicentric Castleman's Disease.

Melanie D Mumau, Michael V Gonzalez, Chunyu Ma, Abiola H Irvine, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Luke Y C Chen, David Koslicki, David C Fajgenbaum

Abstract readLetter
In one paragraph

Article in The New England journal of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Expert Perspective: Diagnosis and Treatment of Castleman Disease.Arthritis & rheumatology (Hoboken, N.J.) · 2026
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Melanie D MumauPerelman School of Medicine, University of Pennsylvania, Philadelphia.
Michael V Gonzalez
Chunyu MaPennsylvania State University, University Park.
Abiola H IrvinePerelman School of Medicine, University of Pennsylvania, Philadelphia.
Mateo Sarmiento BustamantePerelman School of Medicine, University of Pennsylvania, Philadelphia.
Saishravan ShyamsundarPerelman School of Medicine, University of Pennsylvania, Philadelphia.
Luke Y C ChenVancouver General Hospital, Vancouver, BC, Canada.ORCID 0000-0002-9551-2951
David KoslickiPennsylvania State University, University Park.
David C FajgenbaumPerelman School of Medicine, University of Pennsylvania, Philadelphia.ORCID 0000-0002-7367-8184

Funding

mTOR as a Central Regulator of iMCD Pathogenesis and Novel Therapeutic TargetR01HL141408 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Taku Kambayashi · 2018 to 2026
$6.1M
Biomedical Data Translator Development of Autonomous Relay Agent: ARAXOT2TR003428 · NCATS · OREGON STATE UNIVERSITY · PI DEUTSCH, ERIC, KOSLICKI, DAVID · 2020 to 2024
$5.6M
Advanced Research Projects Agency for Health 140D042490001FDA HHS R01 FD007632NCATS NIH HHS OT2 TR003428NCATS NIH HHS OT2TR003428NHLBI NIH HHS R01 HL141408NHLBI NIH HHS R01HL141408U.S. Food and Drug Administration R01FD007632
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39908436
PMCPMC11801236

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.