ReviewPLoS neglected tropical diseases2025
Enteritis necroticans and Clostridium perfringens type C; Epidemiological and pathological findings over the past 20 years.
Review in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Fecal microbiota transplantation from Hezuo pigs alleviates intestinal inflammatory injury in Clostridium perfringens type C-infected piglets via modulation gut microbiota and intestinal barrier.BMC microbiology · 2026Article
- Antibacterial activity and mechanism analysis of deoxycholic acid against Clostridium perfringens.BMC microbiology · 2026Article
- Toxin genotypes and antimicrobial resistance profiles ofVeterinary world · 2026Article
- Milestones in Clostridium perfringens research since 1995.Anaerobe · 2025Review
- Isolation, toxin gene profiling, and phylogenetic analysis of Clostridium perfringens in Egyptian fruit bats: public health and epidemiological implications.Scientific reports · 2025Article
- Antibacterial activity and mechanism analysis of deoxycholic acid against Clostridium perfringens.Research square · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Enteritis necroticans (EN) in humans caused by infection with Clostridium perfringens type C, once thought limited to the highlands of Papua New Guinea has been identified sporadically worldwide. Outbreaks still occur among children in low-income countries and isolated cases occur among children and adults in other countries. Here the disease seems to be associated with diabetes mellitus and other risk factors. C. perfringens type C is also an important cause of necrotizing enteritis among animals, particularly pigs. Research into the pathogenesis of this disease has confirmed the central role of beta toxin and its target, the endothelial cell. Unlike most bacterial enteric infections, the primary anatomic location of EN is the proximal small intestine, reasons for which are not completely understood. Ongoing surveillance for C. perfringens type C infection is warranted as well as public health measures of prevention in locations where environmental and food hygiene is poor.
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Registered trials
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