ArticlePloS one2025
Experimental assessment of damage and microplastic release during cyclic loading of clear aligners.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ageing effects on chemical, physical, mechanical, and morphological properties of clear aligners - a systematic review.Progress in orthodontics · 2026Pooled it
- Clear Aligners as a Prescribed Source of Unmeasured Intra-Oral Micro- and Nanoplastic Exposure: Release Mechanisms, Human Evidence, Salivary Biomonitoring and the EU Regulatory Context.Materials (Basel, Switzerland) · 2026Review
- Aligners do shed microplastics: Evidence is clear, clinical risk is not.Korean journal of orthodontics · 2026Article
- Effects of microplastic release from 3D-printed orthodontic aligners: a histological and immunological bioassay approach.European journal of orthodontics · 2026Article
- Spectrophotometric, Periodontal and Subjective Evaluations on Five Different Products for Clear Aligners Cleansing: Randomised Clinical Trial.International journal of dentistry · 2026Article
- Clear aligner therapy among orthodontists in Turkey: practice patterns and comparison with previously reported Iranian findings.Frontiers in dental medicine · 2026Article
- Microplastics Release From Clear Aligners: A Scoping Review of Current Evidence, Health Implications, and Policy Directions.International journal of dentistry · 2026Review
- Clear aligner therapy beyond esthetics: oral health, polymer materials, and the environmental cost of digital orthodontics.Frontiers in dental medicine · 2026Review
- Evaluating chemical and surface stability of thermoformed and 3D-printed clear aligners after intraoral exposure.PloS one · 2026Article
- Microplastics and nanoplastics in clinical dentistry and orthodontics: leaching, health implications, and future directions: a narrative review.Progress in orthodontics · 2025Review
- Cytotoxicity and Endocrine Disruption in Materials Used for Removable Orthodontic Retainers: A Comprehensive Review.Dentistry journal · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The widespread adoption of clear aligners in orthodontic treatments in recent years has necessitated a more precise examination of the mechanical properties of the devices currently available in orthodontics. Recent studies indicate that aligners, when exposed to the forces exerted during swallowing, undergo fatigue-like phenomena, leading to chip formation and cracks. The cumulative damage results in a compromised fit between the tooth and aligner, which is crucial for the effective execution of orthodontic treatment. Additionally, the formation of chips poses a potential risk to patients, as there is a possibility of inadvertently ingesting microplastics that become detached from the aligner over time. This study attempts to assess the release of microplastics from the aligners subjected to cyclic compressive loading. Three different aligners (Essix Ace, Ghost Aligner and Invisalign) are tested to simulate swallowing conditions over the aligner usage period. The mechanical performance is studied in terms of the energy absorbed by the aligner, which shows that the Essix Ace has a stable energy absorption behaviour, while the energy absorbed by the Invisalign is significantly higher than their counterparts. Ghost Aligner did not perform well in the cyclic compression tests. The microplastics (MPs) released by the aligners are examined under an optical microscope. A dimensional analysis based on k-means image segmentation and edge detection algorithm is developed to analyse the MPs. The dimensional analysis of the MPs revealed that the ingestion of the MPs released by all the three aligners does not pose a health risk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.