Evidence map›Paper›PMID 39908267›Full record

ArticleAging and disease2025

Unveiling Lipid Droplet Transport Dynamics as Biomarkers of Senescence Using Label-Free, Time-Lapse Holotomography.

Amarnath Singam, Nikita Gopakumar, Apoorva Chauhan, Kimberly Ramirez, Jeong Hee Kim, Chandrabali Bhattacharya, Jingchun Chen, Deok-Ho Kim, Seungman Park

Abstract read
In one paragraph

Article in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amarnath SingamDepartment of Mechanical Engineering, University of Nevada, Las Vegas, NV 89154, USA.
Nikita GopakumarDepartment of Mechanical Engineering, University of Nevada, Las Vegas, NV 89154, USA.
Apoorva ChauhanInterdisciplinary Biomedical Engineering Program, University of Nevada, Las Vegas, NV 89154, USA.
Kimberly RamirezDepartment of Mechanical Engineering, University of Nevada, Las Vegas, NV 89154, USA.
Jeong Hee KimDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Chandrabali BhattacharyaInterdisciplinary Biomedical Engineering Program, University of Nevada, Las Vegas, NV 89154, USA.
Jingchun ChenNevada Institute for Personalized Medicine, University of Nevada, Las Vegas, NV 89154, USA.
Deok-Ho KimCenter for Microphysiological Systems, Johns Hopkins University, Baltimore, MD 21218, USA.
Seungman ParkDepartment of Mechanical Engineering, University of Nevada, Las Vegas, NV 89154, USA.

Funding

High-throughput neurovascular-unit-on-a-chip with OASIS for modeling Parkinson's diseaseR01NS133965 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Deok-Ho Kim, Gabsang Lee · 2024 to 2026
$1.8M
Convolutional Neural Network for Disease Prediction, Biomarker Discovery, and Validation in Alzheimer's DiseaseR15AG083618 · NIA · UNIVERSITY OF NEVADA LAS VEGAS · PI Jingchun Chen · 2024 to 2026
$751k
Characterization of relation between tissue viscoelasticity and tumor progression in aging tissuesK25AG070286 · NIA · UNIVERSITY OF NEVADA LAS VEGAS · PI PARK, SEUNGMAN · 2021 to 2025
$734k
NIA NIH HHS K25 AG070286NIA NIH HHS R15 AG083618NINDS NIH HHS R01 NS133965
6 · The paper itself

Abstract

Accumulation and density of lipid droplets (LDs) in cells have been identified as a potential biomarker to detect senescent cells. However, their intracellular dynamic transport and alterations during senescence remain largely unclear. To address this knowledge gap, senescence was induced in human microglia cells using hydrogen peroxide (H

Indexed as

Cellular SenescenceLipid DropletsMicrogliaBiomarkersCell LineHumansHydrogen PeroxideTime-Lapse ImagingBiomarkersHydrogen Peroxide

Identifiers

PMID39908267
PMCPMC12727127

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.